Rümelin A, Dörr S, Fauth U
Klinik für Anästhesiologie, Johannes Gutenberg Universität Mainz, Germany.
Ann Nutr Metab. 2002;46(5):211-4. doi: 10.1159/000065409.
A decrease in ascorbic acid (AA) plasma concentration is well known during the postoperative period and postulated to be caused by increased radical scavenging activity in response to surgical trauma. This often affects postoperative patients and is associated with multiple organ failure. Therefore, substitution of AA could potentially decrease the risk of postoperative complications. This study examines the effect of preoperative oral administration of 1,000 mg AA on the postoperative AA plasma concentration.
54 patients were randomly split into two groups; patients in group 1 received no AA preoperatively while group 2 received oral AA (1,000 mg). Plasma samples were obtained preoperatively and on the first postoperative day for AA analysis (HPLC).
In both groups the AA concentration was normal preoperatively and reduced postoperatively.
A preoperative substitution of 1,000 mg AA is not sufficient to prevent postoperative lowered plasma concentration.
众所周知，术后血浆中抗坏血酸（AA）浓度会降低，据推测这是由于手术创伤引发自由基清除活性增强所致。这一情况常影响术后患者，并与多器官功能衰竭相关。因此，补充AA可能会降低术后并发症的风险。本研究旨在探讨术前口服1000毫克AA对术后血浆AA浓度的影响。
54例患者被随机分为两组；第1组患者术前未接受AA，而第2组患者口服AA（1000毫克）。术前及术后第一天采集血浆样本进行AA分析（高效液相色谱法）。
两组患者术前AA浓度均正常，术后均降低。
术前补充1000毫克AA不足以预防术后血浆浓度降低。
