Irvin T T
Int J Vitam Nutr Res Suppl. 1982;23:277-86.
The postoperative ascorbic acid requirements of 63 surgical patients were assessed by measurement of buffy layer leucocyte ascorbic acid and the ascorbic acid content of white blood cells. There was a significant reduction in ascorbic acid levels following surgery. The postoperative changes were unrelated to the extent of surgical trauma or the volume of blood transfused during surgery but there was a significant correlation between postoperative ascorbic acid measurements and white blood cell counts. It appears that postoperative leucocytosis and release by the bone marrow of white blood cells with a low ascorbic acid content may partly account for the postoperative changes in buffy layer and white blood cell ascorbic acid measurements. However, surgical operations were followed by an authentic increase in ascorbic acid requirements, and there was a 42 per cent reduction in circulating white blood cell ascorbic acid levels on the third postoperative day. The findings of this study create an argument for the use of ascorbic acid supplements in surgical patients although it is unlikely that postoperative changes in leucocyte ascorbic acid have pathologic significance in wound repair.
通过测量血沉棕黄层白细胞中的维生素C含量以及白细胞的维生素C含量，对63例外科手术患者术后的维生素C需求量进行了评估。术后维生素C水平显著降低。术后的变化与手术创伤程度或手术期间输注的血量无关，但术后维生素C测量值与白细胞计数之间存在显著相关性。术后白细胞增多以及骨髓释放低维生素C含量的白细胞可能部分解释了血沉棕黄层和白细胞维生素C测量值的术后变化。然而，外科手术后确实会增加维生素C的需求量，术后第三天循环白细胞中的维生素C水平降低了42%。本研究结果为外科手术患者使用维生素C补充剂提供了依据，尽管白细胞维生素C的术后变化在伤口修复中不太可能具有病理意义。
