Yokoyama T, Sugiyama K, Nishizawa S, Yokota N, Ohta S, Akamine S, Namba H
Department of Neurosurgery, Hamamatsu University School of Medicine, Hamamatsu, Shizuoka, Japan.
Stereotact Funct Neurosurg. 2001;77(1-4):61-7. doi: 10.1159/000064598.
To determine the optimal stimulation site within the subthalamic nucleus (STN), monopolar stimulation of four electrode contacts and the resulting effects on parkinsonian symptoms were evaluated in 10 consecutive patients. The UPDRS score for rigidity and akinesia improved significantly after stimulation at each of the contacts, compared to the pre-evaluation state (Fisher's test, p < 0.05). The most significant improvement was obtained after stimulation at contact-2 (rigidity: 74.4 +/- 20.4%, akinesia: 53.7 +/- 14.3%) (Fisher's test, p < 0.001). Contact-2 was located at the dorsal border of the STN at a mean distance of 0.3 +/- 0.7 mm. DBS at the dorsal border of the STN, where the stimulation affects the neurons as well as their axonal fibers, produces the greatest clinical improvement in parkinsonian symptoms.
为确定丘脑底核（STN）内的最佳刺激部位，对10例连续患者的四个电极触点进行单极刺激，并评估其对帕金森症状的影响。与评估前状态相比，每个触点刺激后，UPDRS量表中强直和运动不能评分均显著改善（Fisher检验，p < 0.05）。触点2刺激后改善最为显著（强直：74.4 +/- 20.4%，运动不能：53.7 +/- 14.3%）（Fisher检验，p < 0.001）。触点2位于STN背侧边界，平均距离为0.3 +/- 0.7毫米。在STN背侧边界进行深部脑刺激（DBS），该部位的刺激会影响神经元及其轴突纤维，能使帕金森症状获得最大程度的临床改善。
