Hirano A, Matsui T, Zimmerman H M
No Shinkei Geka. 1975 Jul;3(7):557-63.
The tumor cells form an unoriented mass rather than a layered structure. Most of the cells have no ependymal specialization, such as cilia, microtubular, etc. Instead, they assume a primitive undifferentiated appearance with large nuclei and abundant free ribosomes. Occasionally, however, certain cells tend to form a ring around a narrow lumen-like space within the mass. Such spaces are virtually filled with microvilli and, occasionally, even cilia arising form the surrounding cells. Elaborate desmosomes decorate the apposing surfaces of such cells and basal bodies are presented within the cytoplasm. In addition, the tumor cells often display glial filaments, glycogen granules and microtubules, similar to the cells comprising astrocytomas. As is well known, astrocytomas and ependymomas are often found mixed in the same tumor.
肿瘤细胞形成无定向的团块而非分层结构。大多数细胞没有室管膜特化结构，如纤毛、微管等。相反，它们呈现出原始未分化的外观，细胞核大且有丰富的游离核糖体。然而，偶尔某些细胞倾向于在团块内围绕一个狭窄的管腔样空间形成环状。这样的空间实际上充满了微绒毛，偶尔甚至有来自周围细胞的纤毛。精细的桥粒装饰着这些细胞相对的表面，细胞质内可见基体。此外，肿瘤细胞常显示出神经胶质细丝、糖原颗粒和微管，类似于构成星形细胞瘤的细胞。众所周知，星形细胞瘤和室管膜瘤常混合存在于同一肿瘤中。
