Uematsu Y, Rojas-Corona R R, Llena J F, Hirano A
Department of Pathology, Montefiore Medical Center, Bronx, NY 20467.
Acta Neuropathol. 1989;78(3):325-8. doi: 10.1007/BF00687763.
The ependyma and choroid plexus of 23 normal brains and 20 ependymal tumors were examined immunohistochemically for expression of epithelial membrane antigen (EMA) using a specific monoclonal antibody. The ependyma of normal brains showed three patterns of immunoreactivity: membrane immunoreactivity confined to the luminal surface; irregular punctate intracytoplasmic immunoreactivity in the subependymal layer; and spherical and ring-like intracytoplasmic immunoreactivity in the subependymal layer. Of 13 differentiated ependymomas 11 reflected the immunoreactive patterns of normal ependyma. The anaplastic ependymomas and ependymoblastomas had no immunoreactivity. Our results indicate that EMA has a highly selective distribution in the ependyma, and is a marker for differentiated ependymoma.
使用一种特异性单克隆抗体，对23例正常脑和20例室管膜瘤的室管膜和脉络丛进行免疫组织化学检查，以检测上皮膜抗原（EMA）的表达。正常脑的室管膜呈现出三种免疫反应模式：局限于管腔表面的膜免疫反应；室管膜下层不规则的点状胞浆内免疫反应；室管膜下层球形和环状的胞浆内免疫反应。13例分化型室管膜瘤中有11例反映了正常室管膜的免疫反应模式。间变性室管膜瘤和室管膜母细胞瘤无免疫反应。我们的结果表明，EMA在室管膜中具有高度选择性分布，是分化型室管膜瘤的标志物。
