Miles J
Pain Relief Foundation, University of Liverpool, UK.
Stereotact Funct Neurosurg. 2001;77(1-4):156-8. doi: 10.1159/000064592.
With the improved utilisation and widespread availability of opiates, the oral treatment of pain due to malignancy has changed radically, so that the expected need for intrathecal (IT) delivery systems for this pain has largely failed to materialise. Instead, the lack of equal progress in the design and production of non-opiates for treating non-malignant pain, in the long term, has resulted in a greater interest in the development of these IT systems in this non-malignant area.
随着阿片类药物利用率的提高和广泛可得性，恶性肿瘤所致疼痛的口服治疗已发生了根本性变化，以至于对用于此类疼痛的鞘内（IT）给药系统的预期需求在很大程度上未能实现。相反，从长远来看，用于治疗非恶性疼痛的非阿片类药物在设计和生产方面缺乏同等进展，导致人们对在这一非恶性领域开发这些IT系统产生了更大兴趣。
