帕罗西汀治疗中CYP 2D6代谢状态与性功能障碍的关系。

Relationship between CYP 2D6 metabolic status and sexual dysfunction in paroxetine treatment.

作者信息

Zourková Alexandra, Hadasová Eva

机构信息

Department of Psychiatry, Masaryk University, Brno, 63900, Czech Republic.

出版信息

J Sex Marital Ther. 2002 Oct-Dec;28(5):451-61. doi: 10.1080/00926230290001565.

DOI:10.1080/00926230290001565

PMID:12378847

Abstract

This article describes the incidence of sexual dysfunction in 30 patients subjected to long-term treatment by paroxetine in dependence on the P 450 CYP 2D6 isoenzyme metabolic status. Measured on the Arizona Sexual Experience Scale (ASEX; McGahuey, Delgado, & Gelenberg, 1999), the incidence of sexual dysfunction in patients converted to CYP 2D6 poor metabolizers was markedly higher compared with patients who had no history of such conversion, a difference that reached the level of statistical significance. Our article discusses the incidence of sexual dysfunction in connection with reduced CYP 2D6 capacity.

摘要

本文描述了30例接受帕罗西汀长期治疗的患者性功能障碍的发生率，该发生率取决于细胞色素P450 2D6（CYP 2D6）同工酶的代谢状态。根据亚利桑那性体验量表（ASEX；McGahuey、Delgado和Gelenberg，1999）进行测量，转化为CYP 2D6慢代谢型的患者性功能障碍的发生率明显高于无此类转化史的患者，这一差异达到了统计学显著水平。我们的文章讨论了与CYP 2D6能力降低相关的性功能障碍的发生率。