Eichelman B, Barchas J
Pharmacol Biochem Behav. 1975 Jul-Aug;3(4):601-4. doi: 10.1016/0091-3057(75)90180-x.
Rats were tested for changes in shock-induced fighting following treatment with antidepressants of both the dibenzazepine and monoamine oxidase inhibitor classes of drug. Rats were retested for shock-induced fighting 3, 4, and 5 days after initial injections of imipramine (10 mg/kg IP bid), or saline. All three dibenzazepine groups showed increased levels of shock-induced fighting (p less than 0-01). In addition, rats were retested for shock-induced fighting 6, 30. 54, and 78 hours following the initiation of treatment with daily injections of saline, or the monoamine oxidase inhibitors: nialamide (100 mg/kg/day), iproniazid (150 mg/kg/day), and pargyline (20 mg/kg/day). All three monoamine oxidase inhibitor groups showed increased levels of shock-induced fighting after 30 hr (p less than 0.001). There was no difference in the jump threshold of rats treated with pargyline or saline.
用二苯并氮䓬类和单胺氧化酶抑制剂类抗抑郁药对大鼠进行治疗后，测试其电击诱发打斗行为的变化。在首次注射丙咪嗪（10毫克/千克腹腔注射，每日两次）或生理盐水后3天、4天和5天，对大鼠再次进行电击诱发打斗行为测试。所有三个二苯并氮䓬类药物组的电击诱发打斗水平均升高（p小于0.01）。此外，在用生理盐水或单胺氧化酶抑制剂每日注射开始治疗后6小时、30小时、54小时和78小时，对大鼠再次进行电击诱发打斗行为测试，这些单胺氧化酶抑制剂包括：尼亚酰胺（100毫克/千克/天）、异烟肼（150毫克/千克/天）和帕吉林（20毫克/千克/天）。所有三个单胺氧化酶抑制剂组在30小时后电击诱发打斗水平均升高（p小于0.001）。接受帕吉林或生理盐水治疗的大鼠的跳跃阈值没有差异。
