Cuadra G R, Molina V A
Departamento de Farmacología, Facultad de Ciencias Químicas, Universidad Nacional de Córdoba, Argentina.
Pharmacol Biochem Behav. 1991 Sep;40(1):69-73. doi: 10.1016/0091-3057(91)90322-s.
Animals were exposed to long-duration inescapable shock (IS) and six days later submitted in pairs to a foot-shock session in order to induce shock-elicited aggression (SIF). Shocked rats subsequently displayed a lower aggressive response as compared to unshocked animals. This reduction was prevented by repeated treatment with different antidepressant drugs administered either prior or following IS exposure. In addition, rats chronically administered with antidepressant drugs before the IS showed less inactivity during the application of the uncontrollable aversive event. These data indicate that persistent administration with these pharmacological compounds prevent the induction and impede the further expression of the reduced aggressive response induced by a previous IS.
将动物暴露于长时间不可逃避的电击（IS）下，六天后将它们成对进行足部电击实验，以诱发电击引发的攻击行为（SIF）。与未受电击的动物相比，受电击的大鼠随后表现出较低的攻击反应。在IS暴露之前或之后给予不同的抗抑郁药物进行重复治疗可防止这种反应降低。此外，在IS之前长期给予抗抑郁药物的大鼠在不可控厌恶事件施加期间表现出较少的无活动状态。这些数据表明，持续给予这些药理化合物可预防先前IS诱导的攻击反应降低的诱导，并阻碍其进一步表达。
