Milicic A, Misra R, Agrawal S, Aggarwal A, Brown M A, Wordsworth B P
Wellcome Trust Centre for Human Genetics, Headington, Oxford, UK.
Ann Rheum Dis. 2002 Nov;61(11):1021-3. doi: 10.1136/ard.61.11.1021.
To investigate the association of the FcgammaRIIIA gene with rheumatoid arthritis (RA) in two genetically distinct groups: a white group from the United Kingdom and a northern Indian group.
The distributions of the two alleles of the FcgammaRIIIA F158V polymorphism were determined in 398 white patients from the United Kingdom and 63 Indian patients with RA and compared with those from 289 United Kingdom and 93 Indian healthy controls, respectively.
Among the Indian patients, the frequency of the rare 158V allele and the proportion of 158VV homozygotes were reduced (relative risk (RR)=0.3, 95% confidence interval (95% CI) 0.1 to 1.1, p<0.06), reaching statistical significance for carrying the 158VV phenotype relative to 158FV or FF (RR=0.2, 95% CI 0.05-0.9, p<0.02). Conversely, no significant deviation in allelic frequencies was noted between the patients and controls from the United Kingdom.
The 158VV phenotype showed a weak protective effect against developing RA in the Indian group. However, this sample was small (resulting in a low power for statistical analysis) and no independent confirmation was found in the larger white United Kingdom group. Thus the FcgammaRIIIA locus is unlikely to be of major importance in causing RA.
在两个基因不同的群体中研究FcγRIIIA基因与类风湿性关节炎（RA）的关联，这两个群体分别是来自英国的白人群体和印度北部群体。
测定了来自英国的398名白人患者以及63名印度RA患者中FcγRIIIA F158V多态性两个等位基因的分布，并分别与289名英国健康对照者和93名印度健康对照者的等位基因分布进行比较。
在印度患者中，罕见的158V等位基因频率和158VV纯合子比例降低（相对风险（RR）=0.3，95%置信区间（95%CI）0.1至1.1，p<0.06），相对于158FV或FF，携带158VV表型具有统计学意义（RR=0.2，95%CI 0.05 - 0.9，p<0.02）。相反，英国患者和对照者之间的等位基因频率未发现显著偏差。
158VV表型在印度群体中对患RA显示出微弱的保护作用。然而，该样本量较小（导致统计分析效能较低），且在更大的英国白人群体中未发现独立验证。因此，FcγRIIIA基因座在引发RA方面不太可能具有重要意义。
