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Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis.补体激活作为抗磷脂抗体诱导妊娠丢失和血栓形成的介质。
Ann Rheum Dis. 2002 Nov;61 Suppl 2(Suppl 2):ii46-50. doi: 10.1136/ard.61.suppl_2.ii46.
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Clinical significance of antiphosphatidylethanolamine antibodies in the so-called "seronegative antiphospholipid syndrome".所谓“血清阴性抗磷脂综合征”中抗磷脂酰乙醇胺抗体的临床意义。
Autoimmun Rev. 2009 Dec;9(2):90-2. doi: 10.1016/j.autrev.2009.03.007. Epub 2009 Mar 20.
3
Opposite Profiles of Complement in Antiphospholipid Syndrome (APS) and Systemic Lupus Erythematosus (SLE) Among Patients With Antiphospholipid Antibodies (aPL).抗磷脂抗体阳性患者的抗磷脂综合征（APS）与系统性红斑狼疮（SLE）中补体的相反特征。
Front Immunol. 2019 May 7;10:885. doi: 10.3389/fimmu.2019.00885. eCollection 2019.
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Role of tissue factor in the maternal immunological attack of the embryo in the antiphospholipid syndrome.组织因子在抗磷脂综合征中母体免疫攻击胚胎中的作用。
Clin Rev Allergy Immunol. 2010 Dec;39(3):160-5. doi: 10.1007/s12016-009-8187-1.
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Antiphospholipid antibodies. A marker for thrombosis and recurrent abortion.抗磷脂抗体。血栓形成和复发性流产的一个标志物。
Clin Rev Allergy. 1994 Fall;12(3):287-96. doi: 10.1007/BF02802323.
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Complement C3 activation is required for antiphospholipid antibody-induced fetal loss.抗磷脂抗体诱导的胎儿丢失需要补体C3激活。
J Exp Med. 2002 Jan 21;195(2):211-20. doi: 10.1084/jem.200116116.
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Role of complement in antiphospholipid antibody-mediated thrombosis.补体在抗磷脂抗体介导的血栓形成中的作用。
Curr Rheumatol Rep. 2007 Jun;9(3):205-11. doi: 10.1007/s11926-007-0033-y.
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Is there an association between complement activation and antiphospholipid antibody-related thrombosis?补体激活与抗磷脂抗体相关血栓形成之间是否存在关联？
Thromb Haemost. 2010 Dec;104(6):1279-81. doi: 10.1160/TH10-06-0410. Epub 2010 Sep 13.
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Anti-phospholipid antibody mediated fetal loss: still an open question from a pathogenic point of view.抗磷脂抗体介导的胎儿丢失：从发病机制角度看仍是一个未解决的问题。
Lupus. 2010 Apr;19(4):453-6. doi: 10.1177/0961203309361351.
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The role of complement in the antiphospholipid syndrome.补体在抗磷脂综合征中的作用。
Curr Dir Autoimmun. 2004;7:133-48. doi: 10.1159/000075690.
引用本文的文献
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Severe thrombocytopenia is associated with adverse pregnancy outcomes in patients with obstetric antiphospholipid syndrome.严重血小板减少症与产科抗磷脂综合征患者的不良妊娠结局相关。
Eur J Med Res. 2025 Jun 9;30(1):465. doi: 10.1186/s40001-025-02675-4.
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Hospitalized patients with positive antiphospholipid antibodies who have low complement levels are at increased risk for death-a retrospective cohort study.伴有低补体水平的抗磷脂抗体阳性住院患者死亡风险增加：一项回顾性队列研究。
Lupus. 2023 Apr;32(5):668-674. doi: 10.1177/09612033231164091. Epub 2023 Mar 23.
3
16th International Congress on Antiphospholipid Antibodies Task Force Report on Antiphospholipid Syndrome Treatment Trends.第十六届抗磷脂抗体国际大会抗磷脂综合征治疗趋势工作组报告。
Lupus. 2020 Oct;29(12):1571-1593. doi: 10.1177/0961203320950461.
4
Plasma glycated CD59 (gCD59), a novel biomarker for the diagnosis, management and follow up of women with Gestational Diabetes (GDM) - protocol for prospective cohort study.血浆糖化 CD59（gCD59）作为一种新型生物标志物，用于诊断、管理和随访妊娠糖尿病（GDM）妇女的前瞻性队列研究方案。
BMC Pregnancy Childbirth. 2020 Jul 18;20(1):412. doi: 10.1186/s12884-020-03090-9.
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Purpura fulminans-like lesions in antiphospholipid syndrome with endothelial C3 deposition.伴有内皮细胞C3沉积的抗磷脂综合征中的暴发性紫癜样病变
JAAD Case Rep. 2018 Oct 12;4(9):956-958. doi: 10.1016/j.jdcr.2018.09.006. eCollection 2018 Oct.
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Obstetric antiphospholipid syndrome.产科抗磷脂综合征
Lupus Sci Med. 2018 Sep 25;5(1):e000197. doi: 10.1136/lupus-2016-000197. eCollection 2018.
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Antibodies Against Complement Components: Relevance for the Antiphospholipid Syndrome-Biomarkers of the Disease and Biopharmaceuticals.抗补体成分抗体：与抗磷脂综合征的相关性——疾病生物标志物与生物制药
Curr Rheumatol Rep. 2017 Jul;19(7):40. doi: 10.1007/s11926-017-0669-1.
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Serum Protein Profile in Women With Pregnancy Morbidity Associated With Antiphospholipid Syndrome.患有与抗磷脂综合征相关的妊娠并发症的女性的血清蛋白谱
J Hum Reprod Sci. 2017 Jan-Mar;10(1):10-17. doi: 10.4103/0974-1208.204018.
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Complement Activation in Arterial and Venous Thrombosis is Mediated by Plasmin.补体在动脉和静脉血栓形成中的激活是由纤溶酶介导的。
EBioMedicine. 2016 Feb 6;5:175-82. doi: 10.1016/j.ebiom.2016.02.011. eCollection 2016 Mar.
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Experimental Malaria in Pregnancy Induces Neurocognitive Injury in Uninfected Offspring via a C5a-C5a Receptor Dependent Pathway.孕期实验性疟疾通过C5a-C5a受体依赖性途径导致未感染后代出现神经认知损伤。
PLoS Pathog. 2015 Sep 24;11(9):e1005140. doi: 10.1371/journal.ppat.1005140. eCollection 2015 Sep.
本文引用的文献
1
The antiphospholipid syndrome.抗磷脂综合征
N Engl J Med. 2002 Mar 7;346(10):752-63. doi: 10.1056/NEJMra002974.
2
Complement C3 activation is required for antiphospholipid antibody-induced fetal loss.抗磷脂抗体诱导的胎儿丢失需要补体C3激活。
J Exp Med. 2002 Jan 21;195(2):211-20. doi: 10.1084/jem.200116116.
3
Complement inhibitor, complement receptor 1-related gene/protein y-Ig attenuates intestinal damage after the onset of mesenteric ischemia/reperfusion injury in mice.补体抑制剂、补体受体1相关基因/蛋白y-Ig可减轻小鼠肠系膜缺血/再灌注损伤发生后的肠道损伤。
J Immunol. 2001 Nov 15;167(10):5921-7. doi: 10.4049/jimmunol.167.10.5921.
4
Complement: a critical test of its biological importance.补体：对其生物学重要性的关键检验。
Immunol Rev. 2000 Dec;178:166-76. doi: 10.1034/j.1600-065x.2000.17801.x.
5
Does aspirin have a role in improving pregnancy outcome for women with the antiphospholipid syndrome? A randomized controlled trial.阿司匹林在改善抗磷脂综合征女性的妊娠结局方面是否有作用？一项随机对照试验。
Am J Obstet Gynecol. 2000 Oct;183(4):1008-12. doi: 10.1067/mob.2000.106754.
6
Antiphospholipid antibodies and the protein C pathway.抗磷脂抗体与蛋白C途径。
J Autoimmun. 2000 Sep;15(2):221-5. doi: 10.1006/jaut.2000.0407.
7
Validation of the Sapporo criteria for antiphospholipid syndrome.抗磷脂综合征的札幌标准验证
Arthritis Rheum. 2000 Feb;43(2):440-3. doi: 10.1002/1529-0131(200002)43:2<440::AID-ANR26>3.0.CO;2-N.
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Antiphospholipid antibodies affect trophoblast gonadotropin secretion and invasiveness by binding directly and through adhered beta2-glycoprotein I.抗磷脂抗体通过直接结合以及通过黏附的β2-糖蛋白I来影响滋养层促性腺激素的分泌和侵袭性。
Arthritis Rheum. 2000 Jan;43(1):140-50. doi: 10.1002/1529-0131(200001)43:1<140::AID-ANR18>3.0.CO;2-P.
9
A critical role for murine complement regulator crry in fetomaternal tolerance.小鼠补体调节因子Crry在母胎耐受中起关键作用。
Science. 2000 Jan 21;287(5452):498-501. doi: 10.1126/science.287.5452.498.
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Affinity purified human antiphospholipid antibodies bind normal term placenta.亲和纯化的人抗磷脂抗体与足月正常胎盘结合。
Lupus. 1999;8(7):525-31. doi: 10.1191/096120399678840756.
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