St Clair E W
Department of Medicine, Division of Rheumatology, Duke University Medical Center, Durham, NC, USA.
Ann Rheum Dis. 2002 Nov;61 Suppl 2(Suppl 2):ii67-9. doi: 10.1136/ard.61.suppl_2.ii67.
Infliximab is a chimeric anti-tumour necrosis factor alpha (TNFalpha) monoclonal antibody with high affinity and binding specificity for human TNFalpha. Results from several well designed, controlled clinical trials show repeated infusions of infliximab with concomitant methotrexate (MTX) treatment can reduce the signs and symptoms of rheumatoid arthritis (RA). This combination of infliximab and MTX also slows the radiological progression of joint damage, decreases functional disability, and improves qualify of life. These remarkably positive results have led to the investigation of infliximab treatment for other rheumatic diseases. Recently, controlled studies have shown treatment with infliximab can benefit patients with active spondyloarthropathy. TNFalpha has fast become an important therapeutic target in rheumatology.
英夫利昔单抗是一种嵌合型抗肿瘤坏死因子α(TNFα)单克隆抗体,对人TNFα具有高亲和力和结合特异性。多项设计良好的对照临床试验结果表明,重复输注英夫利昔单抗并同时使用甲氨蝶呤(MTX)治疗可减轻类风湿关节炎(RA)的体征和症状。英夫利昔单抗与MTX的这种联合治疗还可减缓关节损伤的放射学进展,降低功能残疾,并改善生活质量。这些显著的积极结果促使人们对英夫利昔单抗治疗其他风湿性疾病进行研究。最近,对照研究表明,英夫利昔单抗治疗可使活动性脊柱关节炎患者受益。TNFα已迅速成为风湿病学中的一个重要治疗靶点。