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ATP and control of intracellular growth of mycobacteria by T cells.三磷酸腺苷（ATP）与T细胞对分枝杆菌细胞内生长的控制
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2
ATP-mediated killing of Mycobacterium bovis bacille Calmette-Guérin within human macrophages is calcium dependent and associated with the acidification of mycobacteria-containing phagosomes.三磷酸腺苷（ATP）介导的人巨噬细胞内卡介苗（Mycobacterium bovis bacille Calmette-Guérin）杀伤作用依赖于钙，并与含分枝杆菌吞噬体的酸化有关。
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本文引用的文献

1
Cell damage excites nociceptors through release of cytosolic ATP.细胞损伤通过释放胞质ATP激活伤害感受器。
Pain. 2002 Jan;95(1-2):41-7. doi: 10.1016/s0304-3959(01)00372-4.
2
Intercellular calcium signaling occurs between human osteoblasts and osteoclasts and requires activation of osteoclast P2X7 receptors.细胞间钙信号传导发生在人成骨细胞和破骨细胞之间，并且需要破骨细胞P2X7受体的激活。
J Biol Chem. 2002 Mar 1;277(9):7574-80. doi: 10.1074/jbc.M104608200. Epub 2001 Dec 27.
3
ATP stimulates human macrophages to kill intracellular virulent Mycobacterium tuberculosis via calcium-dependent phagosome-lysosome fusion.三磷酸腺苷（ATP）通过钙依赖性吞噬体-溶酶体融合刺激人类巨噬细胞杀死细胞内的强毒力结核分枝杆菌。
J Immunol. 2001 Sep 15;167(6):3308-15. doi: 10.4049/jimmunol.167.6.3308.
4
ATP-mediated killing of intracellular mycobacteria by macrophages is a P2X(7)-dependent process inducing bacterial death by phagosome-lysosome fusion.巨噬细胞通过ATP介导杀伤细胞内分枝杆菌是一个依赖P2X(7)的过程，该过程通过吞噬体-溶酶体融合诱导细菌死亡。
J Immunol. 2001 Sep 15;167(6):3300-7. doi: 10.4049/jimmunol.167.6.3300.
5
CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism.CD4(+)和CD8(+) T细胞通过一种不依赖穿孔素和Fas/Fas配体的机制杀死细胞内的结核分枝杆菌。
J Immunol. 2001 Sep 1;167(5):2734-42. doi: 10.4049/jimmunol.167.5.2734.
6
ATP-mediated killing of Mycobacterium bovis bacille Calmette-Guérin within human macrophages is calcium dependent and associated with the acidification of mycobacteria-containing phagosomes.三磷酸腺苷（ATP）介导的人巨噬细胞内卡介苗（Mycobacterium bovis bacille Calmette-Guérin）杀伤作用依赖于钙，并与含分枝杆菌吞噬体的酸化有关。
J Immunol. 2001 May 15;166(10):6276-86. doi: 10.4049/jimmunol.166.10.6276.
7
Defective granule exocytosis in Rab27a-deficient lymphocytes from Ashen mice.来自灰鼠的Rab27a缺陷淋巴细胞中的颗粒胞吐缺陷。
J Cell Biol. 2001 Feb 19;152(4):835-42. doi: 10.1083/jcb.152.4.835.
8
Endotoxin activation of macrophages does not induce ATP release and autocrine stimulation of P2 nucleotide receptors.巨噬细胞的内毒素激活不会诱导ATP释放以及P2核苷酸受体的自分泌刺激。
J Immunol. 2000 Dec 15;165(12):7189-98. doi: 10.4049/jimmunol.165.12.7189.
9
Changes in brain cell shape create residual extracellular space volume and explain tortuosity behavior during osmotic challenge.脑细胞形状的变化产生了残余细胞外空间体积，并解释了渗透挑战期间的曲折行为。
Proc Natl Acad Sci U S A. 2000 Jul 18;97(15):8306-11. doi: 10.1073/pnas.150338197.
10
Vgamma9/Vdelta2 T lymphocytes reduce the viability of intracellular Mycobacterium tuberculosis.Vγ9/Vδ2 T淋巴细胞可降低细胞内结核分枝杆菌的活力。
Eur J Immunol. 2000 May;30(5):1512-9. doi: 10.1002/(SICI)1521-4141(200005)30:5<1512::AID-IMMU1512>3.0.CO;2-3.

三磷酸腺苷（ATP）与T细胞对分枝杆菌细胞内生长的控制

ATP and control of intracellular growth of mycobacteria by T cells.

作者信息

Canaday David H, Beigi Reza, Silver Richard F, Harding Clifford V, Boom W Henry, Dubyak George R

机构信息

Department of Medicine, University Hospitals of Cleveland and Case Western Reserve University, Cleveland, Ohio 44109, USA.

出版信息

Infect Immun. 2002 Nov;70(11):6456-9. doi: 10.1128/IAI.70.11.6456-6459.2002.

DOI:10.1128/IAI.70.11.6456-6459.2002
PMID:12379727
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC130300/
Abstract

Extracellular ATP at millimolar concentrations inhibits growth of mycobacteria in human macrophages. Whether T cells can produce sufficient ATP is unknown. CD4(+) and CD8(+) T cells did not release sufficient ATP through either degranulation or lysis of bystander cells to restrict growth of Mycobacterium bovis BCG in monocytes.

摘要

毫摩尔浓度的细胞外ATP可抑制人巨噬细胞中分枝杆菌的生长。T细胞是否能产生足够的ATP尚不清楚。CD4(+)和CD8(+) T细胞通过脱颗粒或旁观者细胞裂解均未释放足够的ATP来限制单核细胞中牛分枝杆菌卡介苗的生长。