• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

1型菌毛和P菌毛特异性黏附在大肠杆菌对神经源性人类膀胱定植中的作用。

Role of type 1 fimbria- and P fimbria-specific adherence in colonization of the neurogenic human bladder by Escherichia coli.

作者信息

Hull Richard A, Donovan William H, Del Terzo Michael, Stewart Colleen, Rogers Margaret, Darouiche Rabih O

机构信息

Department of Molecular Virology and Microbiology, Center for Prostheses Infections, Baylor College of Medicine, Houston, Texas 77030, USA.

出版信息

Infect Immun. 2002 Nov;70(11):6481-4. doi: 10.1128/IAI.70.11.6481-6484.2002.

DOI:10.1128/IAI.70.11.6481-6484.2002
PMID:12379733
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC130346/
Abstract

Recent clinical studies suggest that the deliberate colonization of the human bladder with a prototypic asymptomatic bacteriuria-associated bacterium, Escherichia coli 83972, may reduce the frequency of urinary tract infection in individuals with spinal cord injuries. However, the mechanism by which E. coli 83972 colonizes the bladder is unknown. We examined the role in bladder colonization of the E. coli 83972 genes papG and fimH, which respectively encode P and type 1 receptor-specific fimbrial adhesins. E. coli 83972 and isogenic papGDelta and papGDelta fimHDelta mutants of E. coli 83972 were compared for their capacities to colonize the neurogenic human bladder. Both strains were capable of stable colonization of the bladder. The results indicated that type 1 class-specific adherence and P class-specific adherence, while implicated as significant colonization factors in experiments that employed various animal model systems, were not required for colonization of the neurogenic bladder in human beings. The implications of these results with regard to the selection of potential vaccine antigens for the prevention of urinary tract infection are discussed.

摘要

近期的临床研究表明,用一种典型的无症状菌尿相关细菌——大肠杆菌83972有意地定殖于人类膀胱,可能会降低脊髓损伤患者的尿路感染频率。然而,大肠杆菌83972定殖于膀胱的机制尚不清楚。我们研究了大肠杆菌83972的papG和fimH基因在膀胱定殖中的作用,这两个基因分别编码P菌毛和1型菌毛受体特异性粘附素。比较了大肠杆菌83972及其同基因的papGΔ和papGΔfimHΔ突变体定殖于神经源性人类膀胱的能力。两种菌株都能够在膀胱中稳定定殖。结果表明,虽然在使用各种动物模型系统的实验中,1型菌毛特异性粘附和P菌毛特异性粘附被认为是重要的定殖因素,但在人类神经源性膀胱定殖中并非必需。讨论了这些结果对于选择预防尿路感染的潜在疫苗抗原的意义。

相似文献

1
Role of type 1 fimbria- and P fimbria-specific adherence in colonization of the neurogenic human bladder by Escherichia coli.1型菌毛和P菌毛特异性黏附在大肠杆菌对神经源性人类膀胱定植中的作用。
Infect Immun. 2002 Nov;70(11):6481-4. doi: 10.1128/IAI.70.11.6481-6484.2002.
2
A Newly Identified Group of P-like (PL) Fimbria Genes from Extraintestinal Pathogenic Escherichia coli (ExPEC) Encode Distinct Adhesin Subunits and Mediate Adherence to Host Cells.肠外致病性大肠杆菌(ExPEC)中一组新鉴定的 P 样(PL)菌毛基因,编码不同的黏附亚单位,并介导与宿主细胞的黏附。
Appl Environ Microbiol. 2022 Jul 12;88(13):e0142121. doi: 10.1128/aem.01421-21. Epub 2022 Jun 27.
3
Localization of a domain in the FimH adhesin of Escherichia coli type 1 fimbriae capable of receptor recognition and use of a domain-specific antibody to confer protection against experimental urinary tract infection.1型菌毛大肠杆菌FimH黏附素中能够识别受体的结构域的定位以及使用结构域特异性抗体预防实验性尿路感染。
J Clin Invest. 1997 Sep 1;100(5):1123-36. doi: 10.1172/JCI119623.
4
Decreased predominance of papG class II allele in Escherichia coli strains isolated from adults with acute pyelonephritis and urinary tract abnormalities.从患有急性肾盂肾炎和尿路异常的成人中分离出的大肠杆菌菌株中,II类papG等位基因的优势降低。
J Urol. 2001 Nov;166(5):1643-6.
5
The PapG-adhesin at the tip of P-fimbriae provides Escherichia coli with a competitive edge in experimental bladder infections of cynomolgus monkeys.P菌毛顶端的PapG黏附素在食蟹猴的实验性膀胱感染中赋予大肠杆菌竞争优势。
J Exp Med. 1995 Dec 1;182(6):1695-702. doi: 10.1084/jem.182.6.1695.
6
Virulence properties of Escherichia coli 83972, a prototype strain associated with asymptomatic bacteriuria.大肠杆菌83972的毒力特性,这是一株与无症状菌尿相关的原型菌株。
Infect Immun. 1999 Jan;67(1):429-32. doi: 10.1128/IAI.67.1.429-432.1999.
7
Role of P-fimbrial-mediated adherence in pyelonephritis and persistence of uropathogenic Escherichia coli (UPEC) in the mammalian kidney.P菌毛介导的黏附在肾盂肾炎及尿路致病性大肠杆菌(UPEC)于哺乳动物肾脏中持续存在过程中的作用。
Kidney Int. 2007 Jul;72(1):19-25. doi: 10.1038/sj.ki.5002230. Epub 2007 Mar 28.
8
Discovery of Bacterial Fimbria-Glycan Interactions Using Whole-Cell Recombinant Escherichia coli Expression.使用全细胞重组大肠埃希菌表达发现细菌菌毛-聚糖相互作用。
mBio. 2021 Feb 23;12(1):e03664-20. doi: 10.1128/mBio.03664-20.
9
E. coli virulence factors in children with neurogenic bladder associated with bacteriuria.与菌尿症相关的神经源性膀胱患儿中的大肠杆菌毒力因子。
Pediatr Nephrol. 2006 Mar;21(3):376-81. doi: 10.1007/s00467-005-2133-0. Epub 2005 Dec 31.
10
Fimch antiserum inhibits the adherence of Escherichia coli to cells collected by voided urine specimens of diabetic women.菌毛抗血清可抑制大肠杆菌对从糖尿病女性中段尿标本中收集的细胞的黏附。
J Urol. 2004 Apr;171(4):1589-93. doi: 10.1097/01.ju.0000118402.01034.fb.

引用本文的文献

1
Genotypic and phenotypic characterisation of asymptomatic bacteriuria (ABU) isolates displaying bacterial interference against multi-drug resistant uropathogenic E. Coli.无症状菌尿(ABU)分离株的基因型和表型特征,这些分离株对多药耐药尿路致病性大肠杆菌表现出细菌干扰作用。
Arch Microbiol. 2024 Sep 9;206(10):394. doi: 10.1007/s00203-024-04114-0.
2
Characterization of clumpy adhesion of to human cells and associated factors influencing antibiotic sensitivity.对 与人细胞的粘性黏附特性及影响抗生素敏感性的相关因素的研究。
Microbiol Spectr. 2024 May 2;12(5):e0260623. doi: 10.1128/spectrum.02606-23. Epub 2024 Mar 26.
3
Evaluation of the Pathogenic Potential of Strains Isolated from Eye Infections.对从眼部感染中分离出的菌株的致病潜力评估。
Microorganisms. 2022 May 25;10(6):1084. doi: 10.3390/microorganisms10061084.
4
Differential interleukin-1β induction by uropathogenic Escherichia coli correlates with its phylotype and serum C-reactive protein levels in Korean infants.尿路上皮致病性大肠埃希菌引起的白细胞介素 1β的差异诱导与其在韩国婴儿中的菌型和血清 C 反应蛋白水平相关。
Sci Rep. 2019 Oct 30;9(1):15654. doi: 10.1038/s41598-019-52070-3.
5
Decreased microbiota diversity associated with urinary tract infection in a trial of bacterial interference.在一项细菌干扰试验中,与尿路感染相关的微生物群多样性降低。
J Infect. 2015 Sep;71(3):358-367. doi: 10.1016/j.jinf.2015.05.014. Epub 2015 Jun 3.
6
Signature-tagged mutagenesis and co-infection studies demonstrate the importance of P fimbriae in a murine model of urinary tract infection.签名标签诱变和共感染研究证明了P菌毛在小鼠尿路感染模型中的重要性。
Pathog Dis. 2015 Jun;73(4). doi: 10.1093/femspd/ftv014. Epub 2015 Feb 11.
7
Bacteriophage-mediated control of a two-species biofilm formed by microorganisms causing catheter-associated urinary tract infections in an in vitro urinary catheter model.在体外导尿管模型中,噬菌体介导对由引起导管相关尿路感染的微生物形成的双物种生物膜的控制。
Antimicrob Agents Chemother. 2015 Feb;59(2):1127-37. doi: 10.1128/AAC.03786-14. Epub 2014 Dec 8.
8
Bacteriophages are synergistic with bacterial interference for the prevention of Pseudomonas aeruginosa biofilm formation on urinary catheters.噬菌体与细菌干扰协同作用预防绿脓假单胞菌在导尿管上形成生物膜。
J Appl Microbiol. 2012 Dec;113(6):1530-9. doi: 10.1111/j.1365-2672.2012.05432.x. Epub 2012 Sep 17.
9
Fimbrial profiles predict virulence of uropathogenic Escherichia coli strains: contribution of ygi and yad fimbriae.菌毛图谱预测泌尿道致病性大肠杆菌菌株的毒力:ygi 和 yad 菌毛的作用。
Infect Immun. 2011 Dec;79(12):4753-63. doi: 10.1128/IAI.05621-11. Epub 2011 Sep 12.
10
Waging war against uropathogenic Escherichia coli: winning back the urinary tract.与尿路致病性大肠杆菌作斗争:夺回尿路。
Infect Immun. 2010 Feb;78(2):568-85. doi: 10.1128/IAI.01000-09. Epub 2009 Nov 16.

本文引用的文献

1
Pilot trial of bacterial interference for preventing urinary tract infection.预防尿路感染的细菌干扰初步试验
Urology. 2001 Sep;58(3):339-44. doi: 10.1016/s0090-4295(01)01271-7.
2
P fimbriae enhance the early establishment of Escherichia coli in the human urinary tract.P菌毛增强大肠杆菌在人类泌尿道中的早期定植。
Mol Microbiol. 2000 Nov;38(3):456-64. doi: 10.1046/j.1365-2958.2000.02165.x.
3
Urinary tract infection prophylaxis using Escherichia coli 83972 in spinal cord injured patients.脊髓损伤患者使用大肠杆菌83972预防尿路感染
J Urol. 2000 Mar;163(3):872-7.
4
Virulence properties of Escherichia coli 83972, a prototype strain associated with asymptomatic bacteriuria.大肠杆菌83972的毒力特性,这是一株与无症状菌尿相关的原型菌株。
Infect Immun. 1999 Jan;67(1):429-32. doi: 10.1128/IAI.67.1.429-432.1999.
5
Urodynamic factors influence the duration of Escherichia coli bacteriuria in deliberately colonized cases.尿动力学因素影响故意定植病例中大肠杆菌菌尿的持续时间。
J Urol. 1998 Jun;159(6):2057-62. doi: 10.1016/S0022-5347(01)63246-4.
6
Methods for generating precise deletions and insertions in the genome of wild-type Escherichia coli: application to open reading frame characterization.在野生型大肠杆菌基因组中产生精确缺失和插入的方法:应用于开放阅读框表征
J Bacteriol. 1997 Oct;179(20):6228-37. doi: 10.1128/jb.179.20.6228-6237.1997.
7
Localization of a domain in the FimH adhesin of Escherichia coli type 1 fimbriae capable of receptor recognition and use of a domain-specific antibody to confer protection against experimental urinary tract infection.1型菌毛大肠杆菌FimH黏附素中能够识别受体的结构域的定位以及使用结构域特异性抗体预防实验性尿路感染。
J Clin Invest. 1997 Sep 1;100(5):1123-36. doi: 10.1172/JCI119623.
8
Prevention of mucosal Escherichia coli infection by FimH-adhesin-based systemic vaccination.基于FimH黏附素的全身疫苗接种预防黏膜大肠杆菌感染
Science. 1997 Apr 25;276(5312):607-11. doi: 10.1126/science.276.5312.607.
9
Type 1 fimbrial expression enhances Escherichia coli virulence for the urinary tract.1型菌毛表达增强大肠杆菌对泌尿道的致病性。
Proc Natl Acad Sci U S A. 1996 Sep 3;93(18):9827-32. doi: 10.1073/pnas.93.18.9827.
10
Isogenic P-fimbrial deletion mutants of pyelonephritogenic Escherichia coli: the role of alpha Gal(1-4) beta Gal binding in virulence of a wild-type strain.肾盂肾炎致病性大肠杆菌的同基因P菌毛缺失突变体:αGal(1-4)βGal结合在野生型菌株毒力中的作用。
Mol Microbiol. 1993 Oct;10(1):143-55. doi: 10.1111/j.1365-2958.1993.tb00911.x.