大肠杆菌83972的毒力特性，这是一株与无症状菌尿相关的原型菌株。
Virulence properties of Escherichia coli 83972, a prototype strain associated with asymptomatic bacteriuria.
作者信息
Hull R A, Rudy D C, Donovan W H, Wieser I E, Stewart C, Darouiche R O
机构信息
Department of Microbiology and Immunology, Baylor College of Medicine, University of Texas Health Science Center, Houston, Texas, USA.
出版信息
Infect Immun. 1999 Jan;67(1):429-32. doi: 10.1128/IAI.67.1.429-432.1999.
Abstract
Little is known about bacteria associated with asymptomatic bacteriuria (ABU) with regard to urinary tract colonization mechanisms. In this study, virulence properties of Escherichia coli 83972, a strain that was isolated from a clinical ABU episode, were examined. The genetic potential for expression of P and type 1 pili was demonstrated, and DNA sequences related to type 1C and G (UCA) pilus genes were also detected. However, E. coli 83972 did not express D-mannose-resistant or D-mannose-sensitive hemagglutination after growth under standard conditions in vitro or upon isolation from the urine of colonized test subjects. Limited uroepithelial cell adherence was observed in vivo, and weak D-mannose-sensitive hemagglutination was detected after extended growth in urine in vitro.
摘要
关于与无症状菌尿（ABU）相关的细菌的尿路定植机制，目前了解甚少。在本研究中，检测了从临床ABU病例中分离出的大肠杆菌83972菌株的毒力特性。证实了该菌株具有表达P菌毛和1型菌毛的遗传潜力，并且还检测到了与1C型和G（UCA）菌毛基因相关的DNA序列。然而，大肠杆菌83972在体外标准条件下生长后或从定植受试对象的尿液中分离出来后，并未表现出抗D-甘露糖或对D-甘露糖敏感的血凝反应。在体内观察到其对尿路上皮细胞的黏附有限，并且在体外尿液中长时间生长后检测到微弱的对D-甘露糖敏感的血凝反应。
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