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一组结核分枝杆菌临床分离株在人单核细胞模型中的细胞内生长速率和变异性差异。

Differences in rate and variability of intracellular growth of a panel of Mycobacterium tuberculosis clinical isolates within a human monocyte model.

作者信息

Li Qing, Whalen Christopher C, Albert Jeffrey M, Larkin Rhonda, Zukowski Lynn, Cave M Donald, Silver Richard F

机构信息

Department of Medicine, Case Western Reserve University School of Medicine, and University Hospitals of Cleveland, Cleveland, Ohio 44106, USA.

出版信息

Infect Immun. 2002 Nov;70(11):6489-93. doi: 10.1128/IAI.70.11.6489-6493.2002.

Abstract

Significant differences were observed in the capacities of Mycobacterium tuberculosis clinical isolates to grow within human monocytes. Genotyping indicated that the four most rapidly growing isolates were members of the Beijing strain family. M. tuberculosis strain H37Rv provided more reproducible infection than the clinical isolates or M. tuberculosis Erdman.

摘要

在结核分枝杆菌临床分离株在人单核细胞内生长的能力方面观察到显著差异。基因分型表明,四个生长最快的分离株是北京菌株家族的成员。结核分枝杆菌H37Rv菌株比临床分离株或结核分枝杆菌 Erdman 提供了更可重复的感染。

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本文引用的文献

1
History of H37 strain of tubercle bacillus.结核杆菌H37株的历史
Am Rev Tuberc. 1946 Jul;54:62-6. doi: 10.1164/art.1946.54.1.62.
8
Why is IFN-gamma insufficient to control tuberculosis?为什么γ干扰素不足以控制肺结核?
Trends Microbiol. 1999 Dec;7(12):477-8; author reply 478-9. doi: 10.1016/s0966-842x(99)01611-x.

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