心力衰竭中的一氧化氮：朋友还是敌人？
Nitric oxide in heart failure: friend or foe.
作者信息
Jugdutt Bodh I
机构信息
Walter Mackenzie Helath Sciences Centre, Cardiology Division of the Department of Medicine, University of Alberta, Edmonton, Alberta, Canada.
出版信息
Heart Fail Rev. 2002 Oct;7(4):385-9. doi: 10.1023/a:1020767731450.
PMID:12379823
Abstract
Nitric oxide (NO) is a controversial molecule. It is either beneficial or deleterious. As with NO donors, one reason for this duality is related to the dose. Small doses are highly beneficial, maintaining blood flow in vessels and blood pressure, and protecting against foreign invaders. In high doses, it results in hypotension, forms peroxynitrite which is cytotoxic, and contributes to heart failure.
摘要
一氧化氮（NO）是一种颇具争议的分子。它既有益也有害。与一氧化氮供体一样，这种双重性的一个原因与剂量有关。小剂量时非常有益，可维持血管中的血流和血压，并抵御外来入侵者。大剂量时，它会导致低血压，形成具有细胞毒性的过氧亚硝酸盐，并导致心力衰竭。
Zotero 插件