Perrier D'hauterive S, Charlet-Renard C, Goffin F, Foidart M, Geenen V
Centre d'Immunologie, Université de Liège, Institut de Pathologie CHU B-23, 4000 Liège-Sart Tilman, Belgique.
J Gynecol Obstet Biol Reprod (Paris). 2002 Sep;31(5):440-55.
Embryo implantation is a complex event involving apposition followed by adhesion of the blastocyst to the maternal endometrium, and finally invasion of this endometrium. Though implantation could occur in any human tissue, the endometrium is the only tissue where embryo implantation cannot occur except during a restricted period called the implantation window. During this window, the endometrium is highly receptive to the embryo.
and methods. We reviewed the literature concerning the different factors involved in improved endometrial receptivity and implantation.
Maternal - embryo crosstalk is favored by the implantation window. Endometrial receptivity results from the acquisition of ligands or receptors facilitating apposition, then adhesion of the embryo, or from the loss of components preventing it. The molecular basis of the implantation window remains to be defined.
Despite progress in assisted reproduction technologies, the lack of control of implantation remains a major obstacle to successful pregnancy. It is of prime importance to determine the characteristic features of a receptive endometrium and, among the many markers proposed by in vitro studies, to analyze in humans those demonstrated by knock-out experiments to play a crucial role in mice.
胚胎着床是一个复杂的过程，包括胚泡与母体子宫内膜的附着、黏附，最终侵入子宫内膜。尽管着床可发生在任何人体组织中，但除了在称为着床窗的受限时期外，子宫内膜是唯一不能发生胚胎着床的组织。在此窗口期，子宫内膜对胚胎具有高度接受性。
我们回顾了有关改善子宫内膜接受性和着床的不同因素的文献。
着床窗有利于母胎间的相互作用。子宫内膜的接受性源于获得促进附着及随后胚胎黏附的配体或受体，或源于阻止着床的成分的缺失。着床窗的分子基础仍有待确定。
尽管辅助生殖技术取得了进展，但缺乏对着床的控制仍然是成功妊娠的主要障碍。确定接受性子宫内膜的特征至关重要，并且在体外研究提出的众多标志物中，要分析那些在敲除实验中证明在小鼠中起关键作用的标志物在人体中的情况。
