Klentzeris L D
Department of Biological Sciences, University of Warwick, and Walsgrave Hospital, Coventry, UK.
Hum Reprod. 1997 Nov;12(11 Suppl):170-5.
As implantation approaches the different endometrial components demonstrate certain anatomical and molecular changes. Molecules with an effect on uterine receptivity for blastocyst implantation include integrins, leukaemia inhibitory factor (LIF), interleukin-1 (IL-1) and colony stimulating factor-1 (CSF-1). Although over the past 5 years our understanding of the implantation process has improved dramatically, there are still many unanswered questions. Undisputed morphological, biochemical and molecular markers of uterine receptivity that permit quantification of the human implantation window are still unknown. The factors which regulate the expression of integrins, LIF, CSF-1 and IL-1, the mode of action of these molecules and their role in human implantation remain unclear. Only when these questions are answered shall we be able to apply the molecular aspects of implantation to clinical practice.
随着着床临近，子宫内膜的不同成分会呈现出特定的解剖学和分子变化。对胚泡着床的子宫容受性有影响的分子包括整合素、白血病抑制因子（LIF）、白细胞介素-1（IL-1）和集落刺激因子-1（CSF-1）。尽管在过去5年里，我们对着床过程的理解有了显著提高，但仍有许多问题未得到解答。能够量化人类着床窗的子宫容受性的无可争议的形态学、生化和分子标志物仍然未知。调节整合素、LIF、CSF-1和IL-1表达的因素、这些分子的作用方式及其在人类着床中的作用仍不清楚。只有当这些问题得到解答时，我们才能将着床的分子层面应用于临床实践。
