Macias Benigno, Villa Maria V, Sastre Maria, Castiñeiras Alfonso, Borras Joaquin
Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Salamanca, Spain.
J Pharm Sci. 2002 Nov;91(11):2416-23. doi: 10.1002/jps.10234.
Ofloxacin (oflo) is able to interact with Co(II) and Zn(II) salts to form complexes with the general formula [M(oflo)(2)]. 4H(2)O, (M = Co, Zn). Bonding takes place through one of the oxygen atoms of the carboxylate group (acting as a monodentate) and the oxygen atom of the ketonic group. The IR bands of the carboxylic and ketonic group at 1713 and 1622 cm(-1), respectively, shift to 1615 and 1575 cm(-1) in the complexes. After dissolution in methanol, complex [Co(oflo)(2)]. 4H(2)O crystallizes as [Co(oflo)(2)(MeOH)(2)]. 4MeOH, where Co(II) ion is in an octahedral environment of oxygen atoms. This compound crystallizes in the triclinic system, spatial group P-1, with unit cell dimensions a = 9.3670(12), b = 11.4135(17), c = 11.851(2) A y alpha = 71.999(14), beta = 73.698(12), gamma = 83.528(14) degrees. Magnetic properties (effective magnetic moment 5.02 BM) and visible spectrum (bands at 490, 510, and 1152 nm) are characteristic of such an octahedral geometry. (1)H- and (13)C-NMR spectra of the Zn(II) complex indicate only small structural changes in ofloxacin upon coordination to the metallic site.
氧氟沙星（oflo）能够与钴（II）盐和锌（II）盐相互作用，形成通式为[M(oflo)(2)]. 4H(2)O的配合物（M = Co，Zn）。键合通过羧基的一个氧原子（作为单齿配体）和酮基的氧原子发生。配合物中，羧基和酮基在红外光谱中的吸收带分别位于1713和1622 cm(-1)，位移至1615和1575 cm(-1)。溶解于甲醇后，配合物[Co(oflo)(2)]. 4H(2)O结晶为[Co(oflo)(2)(MeOH)(2)]. 4MeOH，其中Co(II)离子处于氧原子的八面体环境中。该化合物结晶于三斜晶系，空间群为P-1，晶胞参数a = 9.3670(12)，b = 11.4135(17)，c = 11.851(2) Å，α = 71.999(14)，β = 73.698(12)，γ = 83.528(14)°。磁性质（有效磁矩5.02 BM）和可见光谱（490、510和1152 nm处的吸收带）为此类八面体几何结构的特征。锌（II）配合物的(1)H-和(13)C-NMR光谱表明，与金属位点配位后，氧氟沙星的结构仅发生微小变化。
