Ribeiro Evandro L, Campos C De Castro, Crespo A M Costa, Castro Jovirês S, Rocha Frederico P, Alves Marcella, Goulart Mariella S, Cardoso Cléver, Ferreira Wesley, Naves Plínio Lázaro, Soares A José, Miranda Simone R, Pimenta Fabiana C
Departamento em Medicina Tropical e Microbiologia/Imunologia, Universidade Federal de Goiás, Brasil.
Acta Med Port. 2002 May-Jun;15(3):171-4.
The childhood is one of the most propitious period of the life to the occurrence of infection by yeasts of the genus Candida. In children with Down's syndrome, besides the predispose factors to bucal candidiasis; macroglossia, bucal muscular incompetence, frequent respiratory diseases, motor difficulty and immunologic deficit are mentioned as additional elements for this fungus disease. It was verified that the children attacked by this syndrome have much more strains of Candida than other children. The aim of this study was to detect the prevalence of phospholipase producer, Candida on the saliva of children with Down's syndrome. Candida albicans was the only identified specie of Candida. The phospholipase production was found in isolated strains from both of study and control. However, the isolated strains of the group of children with Down's syndrome have strongly present phospholipidolitic.
儿童期是感染念珠菌属酵母菌最有利的时期之一。在唐氏综合征患儿中，除了易患口腔念珠菌病的因素外，巨舌、口腔肌肉功能不全、频繁的呼吸道疾病、运动困难和免疫缺陷被提及为这种真菌病的其他因素。经证实，患该综合征的儿童体内的念珠菌菌株比其他儿童多得多。本研究的目的是检测唐氏综合征患儿唾液中产生磷脂酶的念珠菌的患病率。白色念珠菌是唯一鉴定出的念珠菌种类。在研究组和对照组分离出的菌株中均发现了磷脂酶的产生。然而，唐氏综合征患儿组分离出的菌株磷脂分解活性很强。
