Grudianov A I, Ovchinnikova V V, Serebriakova L E
Stomatologiia (Mosk). 2002;81(4):31-4.
The effects of dicloran gel in combination with antibiotics on salivary lipid peroxidation were evaluated in 18 patients aged 23-68 years with chronic generalized rapidly progressing periodontitis. Lipid peroxidation and activity of antioxidant systems surpassed the normal values 2-4-fold in periodontitis patients before treatment. After therapy with metrogil-dent these parameters decreased (p < 0.05). Injection of dicloran gel before antibiotic therapy induced a decrease in these parameters within approximately 30 min. If dicloran gel was injected after metrogil-dent, the maximum decrease in oxidative processes and antioxidant system activity was observed as soon as in 15 min.
在18名年龄在23至68岁之间患有慢性广泛性快速进展型牙周炎的患者中，评估了双氯酚凝胶联合抗生素对唾液脂质过氧化的影响。在治疗前，牙周炎患者的脂质过氧化和抗氧化系统活性超过正常值2至4倍。用甲硝唑口腔凝胶治疗后，这些参数降低（p<0.05）。在抗生素治疗前注射双氯酚凝胶可使这些参数在约30分钟内降低。如果在使用甲硝唑口腔凝胶后注射双氯酚凝胶，则在15分钟时即可观察到氧化过程和抗氧化系统活性的最大降低。
