Yang H, Wang X, Xu Y, Zhang J
College of Stomatology, West China University of Medical Sciences.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2001 Feb;19(1):35-7.
This study was designed to evaluate the clinical effects of metronidazole ofloxacin gel (MO gel) as an adjunct to conventional therapy for periodontitis.
13 patients with adult periodontitis were selected and each of them had two or more sites with probing depth > or = 4 mm, so totally 35 teeth were included in this study. After conventional therapy, the subjects were randomly divided into three groups: (1) experimental group application with MO gel, (2) standard group application with metronidazole stitus, and (3) control group application with placebo gel. Local application was performed once a week for 12 weeks. Clinical parameters including PD, PAL, GI, BOP, PLI was recorded after 6 weeks and 12 weeks respectively.
All clinical parameters from group of gel and group of metronidazole stilus were better than that from control group, while no significant difference was observed between MO gel group and metronidazole stilus group.
It indicates local application with MO gel treatment as an adjunct to conventional therapy may lead to a more advantageous outcome for periodontitis.
本研究旨在评估甲硝唑氧氟沙星凝胶（MO凝胶）辅助传统疗法治疗牙周炎的临床效果。
选取13例成人牙周炎患者，每位患者有两个或更多探诊深度≥4mm的部位，本研究共纳入35颗牙齿。在进行传统治疗后，将受试者随机分为三组：（1）实验组应用MO凝胶；（2）标准组应用甲硝唑棒；（3）对照组应用安慰剂凝胶。每周局部用药1次，共12周。分别在6周和12周后记录临床参数，包括牙周袋深度（PD）、附着丧失（PAL）、牙龈指数（GI）、探诊出血（BOP）、菌斑指数（PLI）。
凝胶组和甲硝唑棒组的所有临床参数均优于对照组，而MO凝胶组和甲硝唑棒组之间未观察到显著差异。
这表明局部应用MO凝胶辅助传统治疗可能对牙周炎产生更有利的结果。
