Koning Gerben A, Schiffelers Raymond M, Storm Gert
Department of Pharmaceutics, Utrecht Institute for Pharmaceutical Sciences, Faculty of Pharmaceutical Sciences, Utrecht University, The Netherlands.
Endothelium. 2002;9(3):161-71. doi: 10.1080/10623320213631.
In the course of an inflammation, vascular endothelial cells (VECs) are strongly involved in processes like leukocyte recruitment, cytokine production, and angiogenesis. Specific interference in these processes may yield great therapeutic benefit in the treatment of (chronic) inflammatory disorders. Drug targeting to VECs at inflamed sites may allow such intervention. VECs at inflamed sites represent a very well-accessible target cell population for circulating drug-targeting systems, which may also be selectively distinguished from normal VECs by the expression of several cell surface receptors involved in the inflammation. One group of specifically expressed molecules are the adhesion molecules (AMs), which have a major function in adhesion of cells to each other, to the extracellular matrix, or in the adhesion and subsequent recruitment of circulating immune cells. This review describes AMs with regard to their function in the inflammatory disease and their usefulness in functioning as a specific target receptor for drug-targeting approaches in general and with an emphasis on liposome-based drug delivery.
在炎症过程中，血管内皮细胞（VECs）强烈参与白细胞募集、细胞因子产生和血管生成等过程。对这些过程的特异性干预可能在（慢性）炎症性疾病的治疗中产生巨大的治疗益处。将药物靶向炎症部位的VECs可能实现这种干预。炎症部位的VECs是循环药物靶向系统非常容易接近的靶细胞群体，通过参与炎症的几种细胞表面受体的表达，它们也可以与正常VECs选择性区分开来。一组特异性表达的分子是黏附分子（AMs），它们在细胞彼此黏附、与细胞外基质黏附或循环免疫细胞的黏附及随后募集方面具有主要功能。本综述描述了AMs在炎症性疾病中的功能，以及它们作为一般药物靶向方法，尤其是基于脂质体的药物递送的特异性靶受体的有用性。
