开发用于治疗癌症和慢性炎症性疾病的血管靶向策略。

Development of vasculature targeting strategies for the treatment of cancer and chronic inflammatory diseases.

作者信息

Schraa Astrid J, Everts Maaike, Kok Robbert J, Asgeirsdóttir Sigridur A, Meijer Dirk K F, de Leij Lou F M H, Molema Grietje

机构信息

Department of Pathology and Laboratory Medicine, Medical Biology Section, Tumor Immunology Laboratory, Groningen University Institute for Drug Exploration (GUIDE), Groningen, The Netherlands.

出版信息

Biotechnol Annu Rev. 2002;8:133-65. doi: 10.1016/s1387-2656(02)08007-9.

DOI:10.1016/s1387-2656(02)08007-9

PMID:12436918

Abstract

Endothelial cells play a pathological role in cancer and chronic inflammation and are therefore attractive targets for therapeutic intervention. This review focuses on endothelial cell specific drug targeting strategies for the treatment of these diseases. The cellular and molecular processes involved in the activation of endothelial cells in angiogenesis and inflammation will be reviewed. Various target epitopes expressed by activated endothelium suitable for targeting purposes, design and development of drug-carrier complexes, drugs of interest which might interfere with endothelial cell activation, as well as in vitro and in vivo experimental approaches to study (intra) cellular drug delivery will be discussed.

摘要

内皮细胞在癌症和慢性炎症中发挥着病理作用，因此是治疗干预的有吸引力的靶点。本综述聚焦于用于治疗这些疾病的内皮细胞特异性药物靶向策略。将综述血管生成和炎症中内皮细胞激活所涉及的细胞和分子过程。将讨论活化内皮细胞表达的适合靶向目的的各种靶表位、药物载体复合物的设计与开发、可能干扰内皮细胞激活的相关药物，以及研究（细胞内）药物递送的体外和体内实验方法。