Branehög I
Br J Haematol. 1975 Mar;29(3):413-26. doi: 10.1111/j.1365-2141.1975.tb01839.x.
Platelet kinetics were studied in 18 patients with idiopathic thrombocytopenic purpura (ITP) before splenectomy, 1 month and 8 months after splenectomy. A gamma function was used for the calculation of platelet mean life span (MLS). Before splenectomy platelet MLS was greatly reduced and platelet production was 2.8 times normal. The peripheral platelet count and platelet recovery were significantly related to platelet MLS. One month after splenectomy platelet MLS increased appreciably while platelet production decreased but continued to be significantly above normal. These changes together with the removal of the splenic platelet pool resulted in a peripheral platelet count significantly higher than normal and a total platelet mass not differing from normal. Eight months after splenectomy platelet MLS increased slightly but was not significantly different from that found 1 month after splenectomy. Platelet production, however, decreased significantly and became normal. This resulted in a normal peripheral platelet count and a decreased total platelet mass which was significantly lower than in non-splenectomized control subjects. The results suggest that platelet production is regulated by a feed-back mechanism that is governed by the peripheral platelet count. The high platelet count encountered 1 month after splenectomy is due to a sluggishness of this regulatory mechanism.
对18例特发性血小板减少性紫癜（ITP）患者在脾切除术前、术后1个月和8个月时的血小板动力学进行了研究。采用伽马函数计算血小板平均寿命（MLS）。脾切除术前血小板MLS大幅降低，血小板生成是正常的2.8倍。外周血小板计数和血小板回收率与血小板MLS显著相关。脾切除术后1个月，血小板MLS明显增加，而血小板生成减少，但仍显著高于正常水平。这些变化以及脾内血小板池的清除导致外周血小板计数显著高于正常，总血小板量与正常无异。脾切除术后8个月，血小板MLS略有增加，但与术后1个月时无显著差异。然而，血小板生成显著减少并恢复正常。这导致外周血小板计数正常，总血小板量减少，显著低于未行脾切除术的对照受试者。结果表明，血小板生成受外周血小板计数控制的反馈机制调节。脾切除术后1个月出现的高血小板计数是由于这种调节机制迟缓所致。
