Hoban Paul R, Ramachandran Sudarshan, Strange Richard C
Centre for Cell and Molecular Medicine, Keele University School of Medicine, North Staffordshire Hospital, Thornburrow Drive, Stoke-on-Trent ST4 7QB, UK.
Expert Rev Anticancer Ther. 2002 Oct;2(5):570-9. doi: 10.1586/14737140.2.5.570.
Basal cell carcinoma is the most common cancer in Caucasians and its incidence is rising. Whilst not life threatening, the tumor can cause substantial morbidity and because of long follow-up, it places a major burden on healthcare agencies worldwide. Patients with the disease demonstrate wide phenotypic diversity with respect to tumor numbers, rate of tumor appearance and site. The factors involved in patient susceptibility to basal cell carcinoma are not well understood although exposure to ultraviolet radiation in sunlight appears critical. In this review we discuss the role of environmental and genetic factors on predisposition to basal cell carcinoma and illustrate how stratification of the basal cell carcinoma cohort into high-risk subgroups is helpful in identifying factors significant in disease susceptibility.
基底细胞癌是白种人中最常见的癌症，其发病率正在上升。虽然不会危及生命，但这种肿瘤会导致严重的发病情况，并且由于需要长期随访，给全球的医疗机构带来了重大负担。患有这种疾病的患者在肿瘤数量、肿瘤出现率和部位方面表现出广泛的表型多样性。尽管阳光中的紫外线照射似乎至关重要，但人们对患者易患基底细胞癌的相关因素了解并不充分。在这篇综述中，我们讨论环境和遗传因素在基底细胞癌易感性中的作用，并说明将基底细胞癌患者群体分层为高危亚组如何有助于识别在疾病易感性中起重要作用的因素。
