头面部的基底细胞癌、鳞状细胞癌和黑色素瘤。
Basal cell carcinoma, squamous cell carcinoma and melanoma of the head and face.
作者信息
Feller L, Khammissa R A G, Kramer B, Altini M, Lemmer J
机构信息
Department of Periodontology and Oral medicine, Sefako Makgatho Health Sciences University, Medunsa, 0204, South Africa.
Department Periodontology and Oral Medicine, Box D26 School of Dentistry, Sefako Makgatho Health Sciences University, Medunsa, 0204, South Africa.
出版信息
Head Face Med. 2016 Feb 5;12:11. doi: 10.1186/s13005-016-0106-0.
Ultraviolet light (UV) is an important risk factor for cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin. These cancers most commonly affect persons with fair skin and blue eyes who sunburn rather than suntan. However, each of these cancers appears to be associated with a different pattern of UV exposure and to be mediated by different intracellular molecular pathways.Some melanocortin 1 receptor (MC1R) gene variants play a direct role in the pathogenesis of cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma apart from their role in determining a cancer-prone pigmentory phenotype (fair skin, red hair, blue eyes) through their interactions with other genes regulating immuno-inflammatory responses, DNA repair or apoptosis.In this short review we focus on the aetiological role of UV in cutaneous basal cell carcinoma, cutaneous squamous cell carcinoma and cutaneous melanoma of the skin, and on some associated biopathological events.
紫外线（UV）是皮肤基底细胞癌、皮肤鳞状细胞癌和皮肤黑色素瘤的重要风险因素。这些癌症最常影响皮肤白皙、蓝眼睛且容易晒伤而非晒黑的人群。然而，这些癌症似乎与不同的紫外线暴露模式相关，并且由不同的细胞内分子途径介导。一些黑皮质素1受体（MC1R）基因变体除了通过与调节免疫炎症反应、DNA修复或细胞凋亡的其他基因相互作用来决定易患癌症的色素沉着表型（白皙皮肤、红头发、蓝眼睛）外，还在皮肤基底细胞癌、皮肤鳞状细胞癌和皮肤黑色素瘤的发病机制中起直接作用。在这篇简短的综述中，我们重点关注紫外线在皮肤基底细胞癌、皮肤鳞状细胞癌和皮肤黑色素瘤中的病因学作用，以及一些相关的生物病理事件。
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