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加替沙星、另外两种喹诺酮类药物以及五种非喹诺酮类抗菌药物对专性厌氧菌的体外活性

In vitro activities of gatifloxacin, two other quinolones, and five nonquinolone antimicrobials against obligately anaerobic bacteria.

作者信息

Schaumann R, Ackermann G, Pless B, Claros M C, Rodloff A C

机构信息

Institute for Medical Microbiology and Epidemiology of Infectious Diseases, University of Leipzig, Leipzig, Germany.

出版信息

Antimicrob Agents Chemother. 1999 Nov;43(11):2783-6. doi: 10.1128/AAC.43.11.2783.

DOI:10.1128/AAC.43.11.2783
PMID:10543764
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC89560/
Abstract

The activity of the new fluoroquinolone gatifloxacin was compared with those of other quinolones and antimicrobial agents of other classes against 294 anaerobes by the broth microdilution technique. For all strains tested, gatifloxacin MICs at which 50 and 90% of the isolates were inhibited were 0.5 and 2 mg/liter, respectively, and were 3 to 4 dilution steps lower than, e.g., ciprofloxacin.

摘要

采用肉汤微量稀释技术，将新型氟喹诺酮类药物加替沙星与其他喹诺酮类药物及其他类别的抗菌药物针对294株厌氧菌的活性进行了比较。对于所有测试菌株，加替沙星抑制50%和90%分离株的MIC分别为0.5和2毫克/升，比环丙沙星等药物低3至4个稀释度。

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