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Single-step extraction of fluconazole from plasma by ultra-filtration for the measurement of its free concentration by high performance liquid chromatography.通过超滤从血浆中一步提取氟康唑，用于通过高效液相色谱法测定其游离浓度。
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Determination of cefepime and cefpirome in human serum by high-performance liquid chromatography using an ultrafiltration for antibiotics serum extraction.
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Pharmacokinetics of intravenously and intramuscularly administered cefepime in infants and children.头孢吡肟在婴幼儿和儿童中静脉注射及肌肉注射后的药代动力学
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High-performance liquid chromatographic assay for cefepime in serum.
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High-pressure liquid chromatographic analysis of BMY-28142 in plasma and urine.血浆和尿液中BMY - 28142的高压液相色谱分析
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N-oxidation of N-methylpyrrolidine released in vivo from cefepime.头孢吡肟在体内释放出的N-甲基吡咯烷的N-氧化反应。
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Safety, tolerance, and pharmacokinetic evaluation of cefepime after administration of single intravenous doses.单次静脉给药后头孢吡肟的安全性、耐受性及药代动力学评估。
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头孢吡肟在人血浆中滴定的陷阱：体外与血浆和温度相关的药物降解

Pitfalls in cefepime titration from human plasma: plasma- and temperature-related drug degradation in vitro.

作者信息

Bugnon Denis, Giannoni Eric, Majcherczyk Paul, Glauser Michel P, Moreillon Philippe

机构信息

Division of Infectious Diseases, Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois, 1011 Lausanne, Switzerland.

出版信息

Antimicrob Agents Chemother. 2002 Nov;46(11):3654-6. doi: 10.1128/AAC.46.11.3654-3656.2002.

DOI:10.1128/AAC.46.11.3654-3656.2002
PMID:12384385
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC128753/
Abstract

While developing a high-pressure liquid chromatography assay for cefepime in plasma, we observed significant drug degradation at 20 and 37 degrees C but not at 4 degrees C. This plasma-related degradation persisted after protein removal. This warrants caution regarding cefepime assays for pharmacokinetic and pharmacodynamic studies of cefepime in vitro and in vivo.

摘要

在开发一种用于测定血浆中头孢吡肟的高效液相色谱法时，我们观察到在20℃和37℃时药物有显著降解，但在4℃时没有。去除蛋白质后，这种与血浆相关的降解仍然存在。这对于头孢吡肟在体外和体内的药代动力学和药效学研究中的头孢吡肟测定值得谨慎对待。