Jenkins M Y, Mitchell G V
J Nutr. 1975 Dec;105(12):1600-6. doi: 10.1093/jn/105.12.1600.
Male Holtzman rats (78 g) were fed semipurified 16% protein diets for 8 weeks using a food grade soy protein concentrate as the protein source. The basal diet (A) contained added DL-methionine (0.26%) and adequate amounts of vitamins A (14,535 IU/kg as retinyl acetate) and E (60 IU/kg as DL-alpha-tocopheryl acetate) and all other required nutrients. Experimental diets included: (B) basal plus 600 IU of vitamin E/kg; (C) basal plus 6,000 IU of vitamin E/kg; (D) basal plus 2.9 X 10(6) IU of vitamin A/kg; (E) basal plus 2.9 X 10(6) IU of vitamin A plus 600 IU of vitamin E/kg; and (F) basal plus 2.9 X 10(6) IU of vitamin A plus 6,000 IU of vitamin E/kg. Both vitamin A and vitamin E had a significant (P less than 0.05) effect on growth. There was an increase in growth with vitamin E intake and a decrease in growth with vitamin A intake. The net result of these two effects was that the groups fed both vitamins tended to be quite close in mean values to the group fed only the basal diet. Vitamin A significantly (P less than 0.05) increased relative weights of spleen and testes; vitamin E reduced that effect. Vitamin E also significantly (P less than 0.05) reduced relative adrenal weight whereas vitamin A significantly increased it. The two effects tend to cancel each other in the sense that the group fed both vitamins had an average relative adrenal weight quite close to that of the group fed only the basal diet. However, vitamin A still had an effect even when 6,000 IU of vitamin E was fed. The interaction effect of the two vitamins was significant (P less than 0.05) for plasma total protein and liver vitamin A. There was an increase in liver vitamin A with increasing levels of vitamin E in the diet. Blood urea nitrogen and plasma cholesterol were unchanged. A significant interaction of vitamins A and E was found to effect plasma total protein, liver vitamin A, and relative weight of spleen and testes.
雄性霍尔茨曼大鼠（78克）以食品级大豆浓缩蛋白作为蛋白质来源，喂食半纯化的16%蛋白质饮食8周。基础饮食（A）添加了DL-蛋氨酸（0.26%）以及适量的维生素A（以醋酸视黄酯计为14,535国际单位/千克）和维生素E（以DL-α-生育酚醋酸酯计为60国际单位/千克）以及所有其他必需营养素。实验饮食包括：（B）基础饮食加600国际单位维生素E/千克；（C）基础饮食加6,000国际单位维生素E/千克；（D）基础饮食加2.9×10⁶国际单位维生素A/千克；（E）基础饮食加2.9×10⁶国际单位维生素A加600国际单位维生素E/千克；以及（F）基础饮食加2.9×10⁶国际单位维生素A加6,000国际单位维生素E/千克。维生素A和维生素E对生长均有显著（P＜0.05）影响。随着维生素E摄入量增加生长加快，随着维生素A摄入量增加生长减慢。这两种影响的净结果是，同时喂食两种维生素的组的平均值往往与仅喂食基础饮食的组非常接近。维生素A显著（P＜0.05）增加脾脏和睾丸的相对重量；维生素E减轻了这种影响。维生素E还显著（P＜0.05）降低肾上腺相对重量，而维生素A显著增加肾上腺相对重量。从同时喂食两种维生素的组的肾上腺平均相对重量与仅喂食基础饮食的组非常接近的意义上来说，这两种影响往往相互抵消。然而，即使喂食6,000国际单位维生素E，维生素A仍然有影响。两种维生素对血浆总蛋白和肝脏维生素A的相互作用效应显著（P＜0.05）。随着饮食中维生素E水平的升高，肝脏维生素A增加。血尿素氮和血浆胆固醇未发生变化。发现维生素A和E的显著相互作用影响血浆总蛋白、肝脏维生素A以及脾脏和睾丸的相对重量。
