Moodley Prashini, Pillay Chinsamy, Nzimande Gladys, Coovadia Yacoob M, Sturm A Willem
The Africa Centre for Health and Population Studies and The Department of Medical Microbiology, Nelson R. Mandela School of Medicine, University of Natal, Durban, P/Bag 7, 4013, Congella, South Africa.
Int J Antimicrob Agents. 2002 Oct;20(4):248-52. doi: 10.1016/s0924-8579(02)00195-4.
The response of male gonococcal urethritis to a single 250 mg dose of ciprofloxacin versus 500 mg was studied. Both regimens were given in combination with doxycycline in the context of the local syndromic management protocol. There was no significant difference in response between the regimens, inclusive/exclusive of tetracycline susceptible isolates. One patient in the 250 mg arm failed to respond clinically but was microbiologically cured and four patients in the 500 mg arm failed microbiologically but responded clinically. All four isolates had ciprofloxacin MICs </=0.007 mg/l.
研究了男性淋菌性尿道炎单次服用250毫克环丙沙星与500毫克环丙沙星的疗效。在当地综合征管理方案中，两种治疗方案均与多西环素联合使用。无论是否包括四环素敏感菌株，两种治疗方案的疗效均无显著差异。250毫克剂量组有1例患者临床治疗失败，但微生物学治愈；500毫克剂量组有4例患者微生物学治疗失败，但临床有反应。所有4株分离菌的环丙沙星最低抑菌浓度均≤0.007毫克/升。
