Sakaki H
Nihon Heikatsukin Gakkai Zasshi. 1975 Sep;11(3):95-107. doi: 10.1540/jsmr1965.11.95.
Numerous studies have been reported on the roles of the terminal portion of biliary duct in the mechanism of bile excretion. There is as yet no generally agreed conclusion as to functional independence of terminal biliary duct, however. The present study has been performed in rabbits to investigate the effects of prostaglandins and a few other drugs on the terminal portion of common bile duct, with the results leading to the following conclusions: 1) The group of muscles comprising the terminal biliary duct of rabbit intercommunicate with the duodenal longitudinal muscle and no histologic evidence has been observed for the presence of any independent sphincter in this portion. 2) The terminal biliary duct and the adjoining segment of the duodenum display practically the same attitudes on electromyograms. 3) The internal pressures of the duodenum and common bile duct were noted to show changes coinciding with electric discharges in the duodenum or terminal biliary duct, respectively, and not to affect each other. 4) The interrelations observed between discharge and flow rate or internal pressure of the terminal biliary duct indicate that the muscles of this portion possess the function as sphincter. It is suggested, therefore, that bile excretion into the duodenal lumen is effected primarily by relaxation of the terminal biliary duct. 5) Prostaglandin E2 has proven to behave differently toward discharges in the duodenum and terminal biliary duct, viz., facilitation in the former and inhibition in the latter. It would follow that these structures serve mutually independent functions. 6) The effects of prostaglandins on the duodenum and the terminal portion of common bile duct are considered to stem from their direct actions on the musculatures of these regions. 7) The findings stress importance of observations with biologically active substances in tissues in the study aimed at clarification of the biliary excretory function.
关于胆管末端在胆汁排泄机制中的作用，已有大量研究报道。然而，对于胆管末端的功能独立性，目前尚无普遍认可的结论。本研究以兔子为实验对象，探讨了前列腺素和其他几种药物对胆总管末端的影响，结果得出以下结论：1）构成兔胆管末端的肌群与十二指肠纵肌相互连通，且未观察到该部位存在任何独立括约肌的组织学证据。2）胆管末端和十二指肠相邻段在肌电图上表现出几乎相同的状态。3）注意到十二指肠和胆总管的内压分别与十二指肠或胆管末端的放电变化一致，且互不影响。4）在胆管末端观察到的放电与流速或内压之间的相互关系表明，该部位的肌肉具有括约肌功能。因此，提示胆汁排入十二指肠腔主要是通过胆管末端的松弛来实现的。5）已证实前列腺素E2对十二指肠和胆管末端的放电表现不同，即在前者中起促进作用，在后者中起抑制作用。由此可见，这些结构发挥着相互独立的功能。6）前列腺素对十二指肠和胆总管末端的作用被认为源于它们对这些区域肌肉组织的直接作用。7）这些发现强调了在旨在阐明胆汁排泄功能的研究中，观察组织中生物活性物质的重要性。
