前列腺素E1、E2和F2α对活体兔奥迪括约肌电活动的影响。

Effect of prostaglandins E1, E2, and F2 alpha on the electric activity of the sphincter of Oddi in living rabbit.

作者信息

Martinez E, Sarles J C

出版信息

Eur Surg Res. 1983;15(6):322-7. doi: 10.1159/000128376.

Abstract

The effect of prostaglandins (PGs), i.e. PGE1, PGE2 and PGF2 alpha (0.5-32 micrograms/kg), on the electrical activity of the rabbit sphincter of Oddi was studied in vivo. PGs were injected intravenously as a bolus and electrical activity of the sphincter and the duodenum was recorded before and during 15 min after the injection. Variations in biliary pressure were also studied at the same time. PGE1 strongly decreased the activity of the sphincter and biliary pressure which were both increased by PGF2 alpha. Both PGE1 and PGF2 alpha showed a dose-response curve of Michaelis-Menten type. Unexpectedly PGE2 increased at first then decreased electrical activity but not significantly. These effects appeared very early after intravenous injection and were evident with low doses.

摘要

在体内研究了前列腺素（PGs），即前列腺素E1、前列腺素E2和前列腺素F2α（0.5 - 32微克/千克）对兔奥迪括约肌电活动的影响。PGs以单次静脉推注的方式给药，在注射前及注射后15分钟内记录括约肌和十二指肠的电活动。同时也研究了胆管压力的变化。前列腺素E1强烈降低括约肌的活动及胆管压力，而前列腺素F2α则使其升高。前列腺素E1和前列腺素F2α均呈现米氏类型的剂量 - 反应曲线。出乎意料的是，前列腺素E2起初增加然后降低电活动，但变化不显著。这些效应在静脉注射后很快出现，且小剂量时就很明显。