Bona G, Castellino N, Petri A
Clinica Pediatrica, Università degli Studi del Piemonte Orientale A. Avogadro, Novara, Italy.
Minerva Pediatr. 2002 Dec;54(6):553-7.
The aim of our study was to evaluate the age of the onset of pubertal characteristics in a population of Northern Italy and to compare our data with the pubertal staging scale defined by Tanner in 1976. These observations may help us to verify if even in Italy there is a positive secular change in sexual maturation, as has been observed in many European countries. We studied 3510 children (1868 males and 1642 females) aged 6-15 years, born between 1983 and 1996. In every subject sexual maturity was evaluated according to Tanner stages. We calculated the percentile distribution for ages of attainment of B2 and PH2 stages for females and G2, PH2 and testicular volume = or >4 ml (VT4) for males. In females the percentile values for B2 were: 3rd=8.1, 50th=10.5, and 97th=12.6 years. In males the percentile values for G2 and VT4 were: 3rd=8.8 and 9.1 years respectively, 50th=11 years, and 97th=13.4 and 13.3 years respectively. 3rd, 50th, and 97th centiles for pubic hair stage 2 were 8.1, 10.6 and 12.6 years for females and 8.8, 11.2 and 13.4 years for males. For all stages an earlier pubertal development was seen in comparison with Tanner data. One hundred-twenty-five girls had already reached menarche. Median (interquartile range) age at menarche was 11.9 (11.4-12.4) years showing a decrease compared with Tanner values. Our data clearly demonstrate a positive secular trend in pubertal development and point out the need of having updated references values of the timing of sexual maturation for the whole Italian population.
我们研究的目的是评估意大利北部人群青春期特征出现的年龄，并将我们的数据与1976年坦纳定义的青春期分期量表进行比较。这些观察结果可能有助于我们验证，即使在意大利，是否也存在与许多欧洲国家所观察到的类似的青春期性成熟的正向长期变化。我们研究了1983年至1996年出生的3510名6至15岁的儿童（1868名男性和1642名女性）。对每个受试者的性成熟情况根据坦纳分期进行评估。我们计算了女性达到B2期和PH2期以及男性达到G2期、PH2期和睾丸体积=或>4毫升（VT4）的年龄的百分位数分布。在女性中，B2期的百分位数为：第3百分位数=8.1岁，第50百分位数=10.5岁，第97百分位数=12.6岁。在男性中，G2期和VT4期的百分位数分别为：第3百分位数=8.8岁和9.1岁，第50百分位数=11岁，第97百分位数分别为13.4岁和13.3岁。女性阴毛2期的第3、第50和第97百分位数分别为8.1岁、10.6岁和12.6岁，男性为8.8岁、11.2岁和13.4岁。与坦纳的数据相比，所有阶段都出现了更早的青春期发育。125名女孩已经初潮。初潮的中位（四分位间距）年龄为11.9（11.4 - 12.4）岁，与坦纳值相比有所下降。我们的数据清楚地表明青春期发育存在正向长期趋势，并指出需要为整个意大利人群更新性成熟时间的参考值。
