[幽门螺杆菌感染后胃窦内分泌细胞的电子显微镜观察]
[Electron microscopic observation of endocrine cells in the antrum in response to Helicobacter pylori infection].
作者信息
He Yan-Ping, Song Yu-Gang, Liu Lian-Pu, Piao Ying-Jie, He Mei-Rong
机构信息
Institute for Digestive Diseases of PLA, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China.
出版信息
Di Yi Jun Yi Da Xue Xue Bao. 2002 Mar;22(3):239-40.
OBJECTIVE
To observe the ultrastructural changes of the endocrine cells in the antrum after the onset of Helicobacter pylori (Hp) infection.
METHODS
Seven patients with chronic gastritis were included in this study, and toluidine blue staining and rapid urease test were performed to determine the Hp status of the gastric antral mucosa biopsies. Five patients identified as being positive for Hp constituted the test group, leaving the 2 Hp-negative patients serving as control. The endocrine cells in the antrum of the patients were sampled to observe the ultrastructural changes by transmission electron microscopy (TEM).
RESULTS
TEM showed increased electron density of the secretion granules in the endocrine cells, and secretions in the parietal cells were active.
CONCLUSION
The ultrastructural changes of the endocrine cells in the antrum might explain high gastrin levels after the onset of Hp infection.
目的
观察幽门螺杆菌（Hp）感染后胃窦内分泌细胞的超微结构变化。
方法
本研究纳入7例慢性胃炎患者，进行甲苯胺蓝染色和快速尿素酶试验以确定胃窦黏膜活检组织的Hp状态。5例Hp阳性患者组成试验组，2例Hp阴性患者作为对照组。采集患者胃窦内分泌细胞，通过透射电子显微镜（TEM）观察超微结构变化。
结果
TEM显示内分泌细胞中分泌颗粒的电子密度增加，壁细胞分泌活跃。
结论
胃窦内分泌细胞的超微结构变化可能解释了Hp感染后胃泌素水平升高的原因。
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