Mangiarotti Giorgio
Department of Biological Sciences, University of Windsor, 401 Sunset Avenue, Ontario, 9NB 3P4, Canada.
Biochem J. 2003 Mar 1;370(Pt 2):713-7. doi: 10.1042/BJ20020638.
Phosphorylation of ribosomal protein S6 leads to the stabilization of pre-spore specific mRNAs during development of Dictyostelium discoideum. The purification of S6 kinase has allowed the identification of protein S11 as the mRNase specific for pre-spore mRNAs. Methylation of ribosomal protein S31 leads to the destabilization of ribosomal protein mRNAs. The purification of S31 methyltransferase has allowed the identification of protein S29 as the mRNAse specific for ribosomal protein mRNAs.
核糖体蛋白S6的磷酸化在盘基网柄菌发育过程中导致孢子前特异性mRNA的稳定。S6激酶的纯化使得能够鉴定出蛋白S11作为孢子前mRNA特异的核糖核酸酶。核糖体蛋白S31的甲基化导致核糖体蛋白mRNA的不稳定。S31甲基转移酶的纯化使得能够鉴定出蛋白S29作为核糖体蛋白mRNA特异的核糖核酸酶。