Jirásek A, Sebestik V
Cesk Patol. 1975 Aug;11(3):147-52.
Necrosis of the spleen resulting from previous storage of the substance within the cells was produced by intravenous injections of 500 mg and 800 mg, respectively, of ethylpalmitate in 30 male Wistar [VELAZ] rats weighting, on average, 200 g. A certain inhomogeneity of the results indicates differences in tissue susceptibility obviously related to the actual functinal state at the spleen. Ethylpalmitate storage was observed to a lesser degree in the Kupffer cells of the liver and in the cells of pulmonary alveoli and septa. This, however, was unassociated with marked necrosis. Other organs [lymph nodes, bone marrow, thymus, kidney, myocardium] did not display significant changes.
通过分别给30只平均体重200克的雄性Wistar[维拉兹]大鼠静脉注射500毫克和800毫克棕榈酸乙酯，造成脾脏坏死，这是由于之前该物质在细胞内蓄积所致。结果存在一定的不均匀性，表明组织易感性存在差异，这显然与脾脏的实际功能状态有关。在肝库普弗细胞以及肺泡和肺泡间隔细胞中观察到棕榈酸乙酯的蓄积程度较低。然而，这与明显的坏死无关。其他器官[淋巴结、骨髓、胸腺、肾脏、心肌]未显示出明显变化。
