Kumar Shaji, Fonseca Rafael, Dispenzieri Angela, Lacy Martha Q, Lust John A, Wellik Linda, Witzig Thomas E, Gertz Morie A, Kyle Robert A, Greipp Philip R, Rajkumar S Vincent
Division of Hematology and Internal Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Blood. 2003 Mar 1;101(5):1715-7. doi: 10.1182/blood-2002-08-2441. Epub 2002 Oct 17.
Angiogenesis plays an important role in the biology of multiple myeloma (MM) and has prognostic importance in this disease. Solitary plasmacytoma is a localized plasma cell malignancy that progresses to MM in a significant number of patients. We examined if angiogenesis is increased in solitary plasmacytoma and if it can help identify patients likely to progress to myeloma. We studied angiogenesis in plasmacytoma biopsy samples and bone marrow biopsies from 25 patients. High-grade angiogenesis was present in 64% of plasmacytomas. In contrast, bone marrow angiogenesis was low in all patients. Patients with high-grade angiogenesis in the plasmacytoma sample were more likely to progress to myeloma and had a shorter progression-free survival compared with patients with low-grade angiogenesis (P =.02). Angiogenesis is increased in solitary plasmacytoma and is a significant predictor of progression to myeloma and provides further evidence of its importance in the pathogenesis of myeloma.
血管生成在多发性骨髓瘤（MM）生物学中起重要作用，且对该疾病具有预后意义。孤立性浆细胞瘤是一种局限性浆细胞恶性肿瘤，相当一部分患者会进展为MM。我们研究了孤立性浆细胞瘤中血管生成是否增加，以及它是否有助于识别可能进展为骨髓瘤的患者。我们研究了25例患者的浆细胞瘤活检样本和骨髓活检中的血管生成情况。64%的浆细胞瘤存在高级别血管生成。相比之下，所有患者的骨髓血管生成均较低。与低级别血管生成的患者相比，浆细胞瘤样本中存在高级别血管生成的患者更有可能进展为骨髓瘤，且无进展生存期更短（P = 0.02）。孤立性浆细胞瘤中血管生成增加，是进展为骨髓瘤的重要预测指标，并为其在骨髓瘤发病机制中的重要性提供了进一步证据。
