Chak L Y, Cox R S, Bostwick D G, Hoppe R T
Department of Therapeutic Radiology, Stanford University, Medical Center, CA.
J Clin Oncol. 1987 Nov;5(11):1811-5. doi: 10.1200/JCO.1987.5.11.1811.
Twenty patients with solitary plasmacytoma of bone were treated by radiation therapy. Local control was achieved in 19 and most patients developed systemic myeloma. To evaluate disease progression, 65 patients, including 45 from published series, were analyzed. Younger patients seemed less likely to progress (P = .06), but other clinical characteristics including site of involvement and paraprotein status did not influence progression. After dissemination, patients had a clinical course similar to patients with stage I myeloma, with a median survival of 47 months. Overall, patients with solitary plasmacytoma of bone had an indolent course of disease, with a median survival of 10.7 years and a 5-, 10-, and 20-year survival of 75%, 52%, and 37%, respectively.
20例骨孤立性浆细胞瘤患者接受了放射治疗。19例实现了局部控制，大多数患者发展为系统性骨髓瘤。为评估疾病进展情况，对65例患者进行了分析，其中包括已发表系列中的45例。年轻患者似乎进展的可能性较小（P = 0.06），但其他临床特征，包括受累部位和副蛋白状态，并不影响疾病进展。疾病播散后，患者的临床病程与I期骨髓瘤患者相似，中位生存期为47个月。总体而言，骨孤立性浆细胞瘤患者的疾病进程较为惰性，中位生存期为10.7年，5年、10年和20年生存率分别为75%、52%和37%。
