Marciani Luca, Little Sarah L, Snee Janice, Coleman Nicholas S, Tyler Damian J, Sykes John, Jolliffe Ian G, Dettmar Peter W, Spiller Robin C, Gowland Penny A
Magnetic Resonance Centre, School of Physics and Astronomy, Nottingham NG7 2RD, UK.
J Pharm Pharmacol. 2002 Oct;54(10):1351-6. doi: 10.1211/002235702760345428.
Liquid Gaviscon and Gaviscon Advance are established reflux suppressant formulations. This study describes the use of echo-planar magnetic resonance imaging (EPI) to visualise non-invasively intragastric alginate rafts of Liquid Gaviscon and Gaviscon Advance in healthy subjects. Secondly, the feasibility of using relaxation rate (T2(-1)) measurements to monitor changes in the physicochemical properties of the rafts in-vivo is evaluated. Six subjects ingested 500 mL of a liquid meal and received a single dose of 20 mL Liquid Gaviscon or 10 mL Gaviscon Advance on 2 separate visits each and were imaged every 15 min. An alginate raft was observed in the stomach for all subjects and both treatments. The raft was observed to consist of a few large fragments on the majority of the scans for both products. At t = 60 min a raft was still present in all cases. Three-dimensional volume reconstructions showed, for the first time, the spatial distribution of the rafts within the gastric lumen. The T2(-1) data showed potential for assessment of dynamic changes in the physicochemical properties of the alginate rafts in-vivo. We conclude that EPI shows great potential in assessing alginate rafts formation in-vivo.
液状盖胃平（Liquid Gaviscon）和盖胃平加强版（Gaviscon Advance）是公认的抗反流制剂。本研究描述了利用回波平面磁共振成像（EPI）对健康受试者体内液状盖胃平和盖胃平加强版的胃内藻酸盐筏进行无创可视化。其次，评估了使用弛豫率（T2(-1)）测量来监测体内筏的物理化学性质变化的可行性。六名受试者摄入500毫升流食，并在两次单独就诊时分别接受单剂量20毫升液状盖胃平或10毫升盖胃平加强版，每15分钟进行一次成像。所有受试者和两种治疗方法在胃内均观察到藻酸盐筏。在两种产品的大多数扫描中，观察到筏由几个大碎片组成。在t = 60分钟时，所有病例中仍存在筏。三维体积重建首次显示了筏在胃腔内的空间分布。T2(-1)数据显示了评估体内藻酸盐筏物理化学性质动态变化的潜力。我们得出结论，EPI在评估体内藻酸盐筏形成方面显示出巨大潜力。
