Ward W K, Wood M D, Slobodzian E P
Legacy Clinical Research and Technology Center, 1225 NE 2nd Avenue, Portland, OR 97232, USA.
J Med Eng Technol. 2002 Jul-Aug;26(4):158-67. doi: 10.1080/03091900210146950.
The primary objective was to develop a telemetric oxygen sensor designed for implantation in subcutaneous tissue. In the sensor, the platinum indicating electrode was covered with polythene to retard oxygen entry and avoid interference. Given the potential for large indicating electrodes to deplete oxygen in vivo, some sensors were made with very small indicating electrodes. Sensors were tested in the anesthetized rabbit at various oxygen concentrations. Animals were studied 1 and 5 days after implementation. The sensor could detect changes in oxygen in vivo. Measurements were similar at 1 and 5 days and sensors with different sized electrodes yielded similar results. This telemetric implantable amperometric sensor can detect variations in tissue oxygenation and may have applications in cardiopulmonary physiology, continuous glucose monitoring and other related fields.
主要目标是开发一种设计用于植入皮下组织的遥测式氧传感器。在该传感器中，铂指示电极覆盖有聚乙烯以延缓氧气进入并避免干扰。鉴于大型指示电极在体内有耗尽氧气的可能性，一些传感器采用了非常小的指示电极。在不同氧浓度下对麻醉兔体内的传感器进行了测试。在植入后1天和5天对动物进行研究。该传感器能够在体内检测氧气变化。在1天和5天时的测量结果相似，不同尺寸电极的传感器产生相似的结果。这种遥测式可植入电流型传感器能够检测组织氧合的变化，可能在心肺生理学、连续血糖监测及其他相关领域有应用。
