Urbancsek J, Fedorcsák P, Klinga K, Dévényi N, Papp Z, Rabe T, Strowitzki T
First Department of Obstetrics and Gynecology, Semmelweis University Medical School, Budapest, Hungary.
Gynecol Endocrinol. 2002 Aug;16(4):285-92.
We examined the impact of high leptin levels on the secretion of estradiol, inhibin A and inhibin B in obese and lean women during ovarian stimulation. Patients undergoing long-term pituitary suppression, ovarian stimulation and in vitro fertilization for non-endocrine reasons were included in this case-control study. Obese women (body mass index (BMI) > 28 kg/m(2); n = 17) were individually matched with lean women (BMI 20-25 kg/m(2); n = 17) for age and baseline follicle stimulating hormone and luteinizing hormone concentrations. Blood samples were collected in a previous menstrual cycle and 1-3 days apart throughout ovarian stimulation. Serum levels of estradiol, leptin, inhibin A and inhibin B were measured. Obese and lean women had similar serum concentrations of estradiol, inhibin A and inhibin B in the follicular and luteal phases of the spontaneous menstrual cycle, and throughout ovarian stimulation. Serum levels of leptin were higher in obese than in lean women, and increased during stimulation in both groups. In the obese group, area-under-the-curve (AUC) leptin levels correlated with AUC inhibin A levels. In the lean group, there was no correlation between AUC leptin levels and AUC levels of ovarian hormones. The results suggest that high leptin concentrations in vivo are not associated with impaired secretion of estradiol and dimeric inhibins during ovarian stimulation.
我们研究了高瘦素水平对肥胖和消瘦女性在卵巢刺激期间雌二醇、抑制素A和抑制素B分泌的影响。本病例对照研究纳入了因非内分泌原因接受长期垂体抑制、卵巢刺激和体外受精的患者。将肥胖女性（体重指数（BMI）>28 kg/m²；n = 17）与消瘦女性（BMI 20 - 25 kg/m²；n = 17）按年龄以及基础促卵泡激素和促黄体生成素浓度进行个体匹配。在既往月经周期以及整个卵巢刺激过程中每隔1 - 3天采集血样。检测血清雌二醇、瘦素、抑制素A和抑制素B水平。肥胖和消瘦女性在自然月经周期的卵泡期和黄体期以及整个卵巢刺激过程中，血清雌二醇、抑制素A和抑制素B浓度相似。肥胖女性的血清瘦素水平高于消瘦女性，且两组在刺激过程中瘦素水平均升高。在肥胖组中，曲线下面积（AUC）瘦素水平与AUC抑制素A水平相关。在消瘦组中，AUC瘦素水平与卵巢激素的AUC水平之间无相关性。结果表明，体内高瘦素浓度与卵巢刺激期间雌二醇和二聚体抑制素分泌受损无关。
