Nagata Chisato, Takatsuka Naoyoshi, Shimizu Hiroyuki
Department of Public Health, Gifu University School of Medicine, Japan.
Am J Epidemiol. 2002 Nov 1;156(9):824-31. doi: 10.1093/aje/kwf118.
The relation between intake of fish and soy products and subsequent all-cause and cause-specific mortality was examined in a cohort of 13,355 male and 15,724 female residents of Takayama, Gifu, Japan. A diet that included soy and fish intake was assessed in 1992 by using a validated semiquantitative food frequency questionnaire. Over 7 years of follow-up, 2,062 participants (1,163 men and 899 women) died. For men, the highest compared with the lowest quintile of total soy product intake was marginally significantly inversely associated with total mortality after adjustment for total energy and nondietary covariates (hazard ratio = 0.83, 95% confidence interval: 0.69, 1.01; p for trend = 0.07). After adjustment for nondietary covariates, a decreased hazard ratio for the highest compared with the lowest quintile of total soy product intake was also observed for women (hazard ratio = 0.83, 95% confidence interval: 0.68, 1.02; p for trend = 0.04). Additional adjustment for dietary factors significantly associated with total mortality did not attenuate these associations. For women but not for men, n-3 fatty acids from fish were significantly inversely associated with total mortality. Results showed that soy intake may have moderate but beneficial effects on total mortality.
在日本岐阜县高山市的13355名男性和15724名女性居民队列中，研究了鱼类和大豆制品摄入量与随后的全因死亡率及特定病因死亡率之间的关系。1992年通过使用经过验证的半定量食物频率问卷对包括大豆和鱼类摄入量的饮食进行了评估。在7年多的随访中，2062名参与者（1163名男性和899名女性）死亡。对于男性，在调整总能量和非饮食协变量后，大豆制品总摄入量最高五分位数与最低五分位数相比，与总死亡率呈边缘显著负相关（风险比=0.83，95%置信区间：0.69，1.01；趋势p值=0.07）。在调整非饮食协变量后，女性中大豆制品总摄入量最高五分位数与最低五分位数相比，风险比也降低（风险比=0.83，95%置信区间：0.68，1.02；趋势p值=0.04）。对与总死亡率显著相关的饮食因素进行额外调整并没有减弱这些关联。对于女性而非男性，鱼类中的n-3脂肪酸与总死亡率显著负相关。结果表明，大豆摄入量可能对总死亡率有适度但有益的影响。
