大鼠脑单胺代谢变化与二氧化碳诱发的失忆
Changes in brain monoamine metabolism and carbon dioxide induced amnesia in the rat.
作者信息
Leonard B E, Rigter H
出版信息
Pharmacol Biochem Behav. 1975 Sep-Oct;3(5):775-80. doi: 10.1016/0091-3057(75)90106-9.
The effect of treatment with carbon dioxide (CO2) on the performance of rats 24 hr after receiving a foot shock in a passive avoidance task was studied. Foot shock induced avoidance. Carbon dioxide produced retrograde amnesia for the foot shock induced avoidance response. Changes in brain monoamine metabolism were studied in groups of rats which had been treated with CO2, foot shock or foot shock +CO2. The rats were killed 24 hr after treatment. Changes mainly occurred in the brain stem and hippocampus. In the rats which had received foot shock alone, brain stem and hippocampal serotonin concentration were raised. This rise was not observed when the foot shock was followed by CO2 treatment. Furthermore, it was found that there was an increased release of noradrenaline in those rats subjected to foot shock alone but a decreased release of this amine in the group which received foot shock followed by CO2. It is suggested that the amnesic effect of CO2 parallels changes in brain serotonin and noradrenaline metabolism.
研究了在被动回避任务中，给予大鼠足部电击24小时后，二氧化碳（CO₂）处理对其行为表现的影响。足部电击会诱导回避行为。二氧化碳会导致对足部电击诱导的回避反应产生逆行性遗忘。对接受过二氧化碳、足部电击或足部电击+二氧化碳处理的大鼠组的脑单胺代谢变化进行了研究。处理后24小时处死大鼠。变化主要发生在脑干和海马体。仅接受足部电击的大鼠，脑干和海马体中的血清素浓度升高。在足部电击后进行二氧化碳处理的大鼠中未观察到这种升高。此外，发现仅接受足部电击的大鼠去甲肾上腺素释放增加，而接受足部电击后再进行二氧化碳处理的组中该胺的释放减少。提示二氧化碳的遗忘效应与脑血清素和去甲肾上腺素代谢的变化平行。
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