Spignoli G, Pepeu G
Eur J Pharmacol. 1986 Jul 31;126(3):253-7. doi: 10.1016/0014-2999(86)90055-5.
In the rat, 1 min following electroshock (ECS) a 46 and 39% decrease in acetylcholine levels was found in the hippocampus and cerebral cortex, respectively. The decrease in the hippocampus was still statistically significant 30 min after ECS. The ECS applied 1 min after training also disrupted the performance of a passive avoidance conditioned response ('step down') tested 30 min later. Oxiracetam (100 and 300 mg/kg i.p.) administered 90 min before training prevented, in a dose-dependent manner, the decrease of acetylcholine in the cerebral cortex and hippocampus. Oxiracetam prevented the ECS disruption of the acquisition of a passive avoidance response. At the dose of 300 mg/kg the acetylcholine level 1 min after ECS was significantly higher than in the sham-treated rats. Piracetam at the same doses was inactive. These results support the hypothesis that oxiracetam may prevent the disruption of the conditioned response by acting on cortical and hippocampal cholinergic mechanisms.
在大鼠中，电击惊厥（ECS）1分钟后，海马体和大脑皮层中的乙酰胆碱水平分别下降了46%和39%。ECS后30分钟，海马体中的下降仍具有统计学意义。训练后1分钟施加的ECS也干扰了30分钟后测试的被动回避条件反应（“步下”）的表现。训练前90分钟腹腔注射奥拉西坦（100和300毫克/千克）以剂量依赖的方式防止了大脑皮层和海马体中乙酰胆碱的减少。奥拉西坦阻止了ECS对被动回避反应习得的干扰。在300毫克/千克的剂量下，ECS后1分钟的乙酰胆碱水平明显高于假处理大鼠。相同剂量的吡拉西坦无活性。这些结果支持了这样的假设，即奥拉西坦可能通过作用于皮层和海马胆碱能机制来防止条件反应的破坏。
