大鼠海马单胺代谢与二氧化碳诱导的逆行性遗忘梯度

Hippocampal monoamine metabolism and the CO2 induced retrograde amnesia gradient in rats.

作者信息

Rigter H, Van Eys G, Leonard B E

出版信息

Pharmacol Biochem Behav. 1975 Sep-Oct;3(5):781-5. doi: 10.1016/0091-3057(75)90107-0.

Abstract

It was found that in rats a gradient of retrograde amnesia for a passive avoidance response could be established when carbon dioxide (CO2) was used as the amnesic agent. The extent of passive avoidance increased as the period between application of a mild foot shock and CO2 treatment was increased. The amnesia gradient was found to cover a period of at least 60 min. Changes in hippocampal serotonin metabolism parallelled the amnesia gradient. Thus, the concent increased. The changes in hippocampal noradrenaline and dopamine did not correlate with the amnesia gradient.

摘要

研究发现，当使用二氧化碳（CO₂）作为遗忘剂时，在大鼠中可以建立被动回避反应的逆行性遗忘梯度。随着轻度足部电击与CO₂处理之间的时间间隔增加，被动回避的程度也会增加。发现遗忘梯度覆盖至少60分钟的时间段。海马中血清素代谢的变化与遗忘梯度平行。因此，浓度增加。海马中去甲肾上腺素和多巴胺的变化与遗忘梯度无关。