Pérez-Ruiz C, Prado-Alcalá R A
Laboratorio de Psicofisiología, Escuela de Psicología, Universidad Anáhuac, México, D.F., México.
Brain Res Bull. 1989 Apr;22(4):599-603. doi: 10.1016/0361-9230(89)90076-2.
A variety of manipulations which interfere with the activity of the striatum, including cholinergic blockade and spreading depression, produce amnesia. However, it has been demonstrated that with overtraining, striatal spreading depression and injections of anticholinergic drugs do not produce memory deficits in positively-rewarded tasks. In the present experiment 2% lidocaine was injected into the striatum shortly after training of passive avoidance, using three levels of footshock (0.2, 0.3, and 0.4 mA). Highly significant retention deficits were produced when the lower intensities were studied; in contrast, the animals trained with 0.4 mA showed near-perfect performance. The data show that the enhanced learning experience, which may be equivalent to overtraining, also protects against memory deficits in negatively-rewarded behaviors, and suggest that it induces a transfer of mnemonic functions from the striatum to other neural structures.
多种干扰纹状体活动的操作，包括胆碱能阻断和扩散性抑制，都会导致失忆。然而，已经证明，经过过度训练后，纹状体扩散性抑制和注射抗胆碱能药物在正向奖励任务中不会产生记忆缺陷。在本实验中，在被动回避训练后不久，将2%利多卡因注射到纹状体中，使用三种强度的足部电击（0.2、0.3和0.4毫安）。当研究较低强度时，产生了高度显著的记忆保持缺陷；相比之下，接受0.4毫安训练的动物表现近乎完美。数据表明，增强的学习体验，可能等同于过度训练，也能防止负向奖励行为中的记忆缺陷，并表明它会促使记忆功能从纹状体转移到其他神经结构。
