Albert D J, Richmond S E
Physiol Behav. 1975 Sep;15(3):339-47. doi: 10.1016/0031-9384(75)90102-x.
Following large septal lesions, male hooded rats were tested for reactivity 2, 7, and 14 days postoperatively. The results showed that lesions which destroyed the septal nuclei bilaterally caused a significant increase in reactivity above that of an operated control group. A similar increase in reactivity was produced by lesions which damaged the bed nucleus of the stria terminalis as well as the septum. A significantly greater level of reactivity was produced when the lesion destroyed the septum and in addition the area ventral to the anterior septum, including parts of the diagonal band of Broca and the accumbens nucleus. A second experiment examined the effectiveness of more restricted lesions ventral to the septum on reactivity. Ventral lesions which destroyed primarily the bed nucleus of the stria terminalis caused a small but significant increase in reactivity. With lesions ventral to the anterior septum the increase in reactivity was significantly larger. The increase in reactivity produced by the anterior-ventral lesions was also larger than that produced by lesions of the septum but it was not as great as that produced by combined lesions of the septum and the anterior-ventral area. These results suggest that several areas contribute to the hyperreactivity that is usually attributed to septal lesions.
在大型间隔损伤后，对雄性带帽大鼠在术后2天、7天和14天进行反应性测试。结果表明，双侧破坏间隔核的损伤导致反应性显著高于手术对照组。破坏终纹床核以及间隔的损伤也产生了类似的反应性增加。当损伤破坏间隔以及前间隔腹侧区域，包括部分布洛卡斜带和伏隔核时，产生的反应性水平显著更高。第二个实验研究了间隔腹侧更局限损伤对反应性的影响。主要破坏终纹床核的腹侧损伤导致反应性有小幅但显著的增加。在前间隔腹侧进行损伤时，反应性的增加显著更大。前腹侧损伤产生的反应性增加也大于间隔损伤产生的反应性增加，但不如间隔和前腹侧区域联合损伤产生的反应性增加大。这些结果表明，几个区域导致了通常归因于间隔损伤的反应过度。
