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[具有对机械刺激敏感壁的血管的简单模型]

[A simple model of a vessel with a wall sensitive to mechanical stimuli].

作者信息

Regirer S A, Shadrina N Kh

机构信息

Institute of Mechanics, Lomonosov Moscow State University, Vorob'evy Gory, Moscow, 119899 Russia.

出版信息

Biofizika. 2002 Sep-Oct;47(5):908-13.

PMID:12397965
Abstract

Smooth muscles in the walls of small blood vessels under normal conditions are always moderately active, so that there is a certain reserve for blood flow adaptation to changed conditions by either narrowing or expanding of the vessel lumen. The previous studies of small vessel hydrodynamics have shown that the activity can cause specific instability of vessel steady states. In order to trace qualitatively the influence of numerous factors on the active state of the vessel, a simplified model of the vessel was proposed, which is reduced to a nonlinear ordinary equation of the first order with delayed argument.

摘要

在正常情况下,小血管壁中的平滑肌总是适度活跃,以便在血管腔通过变窄或扩张来适应变化的条件时,血流有一定的储备。先前对小血管流体动力学的研究表明,这种活跃性会导致血管稳态出现特定的不稳定性。为了定性地追踪众多因素对血管活跃状态的影响,提出了一种简化的血管模型,该模型简化为一个具有延迟自变量的一阶非线性常微分方程。

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Annu Rev Fluid Mech. 2005 Jan 1;37:43-69. doi: 10.1146/annurev.fluid.37.042604.133933.